FB2024_03 , released June 25, 2024
Allele: Dmel\c(2)MUASp.Tag:HA
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General Information
Symbol
Dmel\c(2)MUASp.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0147244
Feature type
allele
Associated gene
Dmel\c(2)M
Associated Insertion(s)
Carried in Construct
P{UASp-c(2)M.HA}
Key Links
Transgenic product class
cDNA
(Manheim and McKim, 2003)
wild_type
(Manheim and McKim, 2003)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Manheim and McKim, 2003)
wild_type
(Manheim and McKim, 2003)
Mutagen
in vitro construct
(Manheim and McKim, 2003)
Progenitor genotype
Carried in construct
P{UASp-c(2)M.HA}
Cytology
Description

UASp sequences drive expression of a c(2)M cDNA tagged with three copies of Tag:HA.

(Manheim and McKim, 2003)
Allele components
Component
Use(s)
Regulatory region(s)
UASp
Encoded product / tool
c(2)M
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4VP16.nanos.UTR/c(2)MUASp.Tag:HA rescues c(2)MZ0810/c(2)MEP2115

      (Gyuricza et al., 2016)

      Scer\GAL4VP16.nanos.UTR/c(2)MUASp.Tag:HA rescues c(2)MZ0810

      (Manheim and McKim, 2003)
      Partially rescues

      c(2)MUASp.Tag:HA/Scer\GAL4hs.PB partially rescues c(2)MZ0810/c(2)MEP2115

      (Gyuricza et al., 2016)
      Fails to rescue

      c(2)MUASp.Tag:HA/Scer\GAL4VP16.bam fails to rescue c(2)MZ0810/c(2)MEP2115

      (Gyuricza et al., 2016)
      Comments

      A 1hr heat-shock induced pulse of expression of c(2)MScer\UAS.P\T.T:Ivir\HA1 (controlled by Scer\GAL4hs.PB) partially reduced the chromosome nondisjunction frequency in the eggs laid 7-10 days after the heat-shock (these would have been in the germarium at the time of the heat-shock), Scer\GAL4bam.T:Hsim\VP16-driven expression of c(2)MScer\UAS.P\T.T:Ivir\HA1 fails to rescue the nondisjunction phenotype, in contrast to expression driven by Scer\GAL4nos.UTR.T:Hsim\VP16 which results in full rescue.

      (Gyuricza et al., 2016)

      c(2)MScer\UAS.P\T.T:Ivir\HA1 driven by Scer\GAL4nos.UTR.T:Hsim\VP16 almost fully rescues the non-disjunction phenotype seen in c(2)MZ0810.

      (Manheim and McKim, 2003)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      c(2)MScer\UAS.P\T.T:Ivir\HA1
      c(2)MScer\UAS.T:Ivir\HA1
      c(2)MUASp.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (5)