FlyBase Allele Report: Dmel\InR[ex15]

General Information

Symbol

Dmel\InR^ex15

Species

D. melanogaster

Name

FlyBase ID

FBal0147836

Feature type

allele

Associated gene

Dmel\InR

Associated Insertion(s)

Carried in Construct

Also Known As

dinr^ex15

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | somatic clone

(Mann et al., 2012, Song et al., 2003)

Phenotype Manifest In

embryonic/larval optic lobe | somatic clone

(Song et al., 2003)

lamina anlage | somatic clone

(Song et al., 2003)

medulla | somatic clone

(Song et al., 2003)

medulla anlage | somatic clone

(Song et al., 2003)

photoreceptor neuron | somatic clone

(Mann et al., 2012)

Detailed Description

Statement

Reference

Single photoreceptors mutant for InR^ex15 survive, but axons have an altered morphology and the axonal process is very thin compared with wild type axons. All analysed R8 photoreceptors correctly target the M3 layer.

(Mann et al., 2012)

InR^ex15 mutants show no defects in opsin regulation.

(Mikeladze-Dvali et al., 2005)

In mosaic larvae in which homozygous clones have been induced in the eye, photoreceptor cell axons project normally through the optic stalk but fail to target the optic lobe properly. The axons cross and terminate prematurely, resulting in gaps and densely packed regions in the lamina. In the medulla, projections fail to form the staggered projections seen in the wild type and the growth cones terminate in thick blunt ends. The pattern of R7 and R8 projections in the medulla shows defects in mosaic adults in which homozygous clones have been induced in the eye; crossing of fibres and gaps in the R7 layer are seen. Heterozygotes have normal photoreceptor cell projections in the medulla.

(Song et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

InR[+]/InR^ex15 is a suppressor of abnormal neuroanatomy phenotype of Scer\GAL4^GMR.PF, gogo^Scer\UAS.T1

(Mann et al., 2012)

Other

Statement

Reference

InR^ex15, dock⁰⁴⁷²³ has abnormal neuroanatomy phenotype

(Song et al., 2003)

InR^ex15, dock¹³⁴²¹ has abnormal neuroanatomy phenotype

(Song et al., 2003)

InR[+]/InR^ex15, dock⁰⁴⁷²³ has abnormal neuroanatomy phenotype

(Song et al., 2003)

InR[+]/InR^ex15, dock¹³⁴²¹ has abnormal neuroanatomy phenotype

(Song et al., 2003)

Phenotype Manifest In

Suppressor of

Statement

Reference

InR[+]/InR^ex15 is a suppressor of photoreceptor cell R8 phenotype of Scer\GAL4^GMR.PF, gogo^Scer\UAS.T1

(Mann et al., 2012)

InR[+]/InR^ex15 is a suppressor of medulla layer M1 phenotype of Scer\GAL4^GMR.PF, gogo^Scer\UAS.T1

(Mann et al., 2012)

Other

Statement

Reference

InR^ex15, dock⁰⁴⁷²³ has medulla anlage phenotype

(Song et al., 2003)

InR[+]/InR^ex15, dock¹³⁴²¹ has medulla anlage phenotype

(Song et al., 2003)

InR[+]/InR^ex15, dock¹³⁴²¹ has medulla phenotype

(Song et al., 2003)

InR[+]/InR^ex15, dock⁰⁴⁷²³ has medulla anlage phenotype

(Song et al., 2003)

InR^ex15, dock⁰⁴⁷²³ has medulla phenotype

(Song et al., 2003)

InR^ex15, dock¹³⁴²¹ has medulla anlage phenotype

(Song et al., 2003)

InR^ex15, dock¹³⁴²¹ has medulla phenotype

(Song et al., 2003)

InR[+]/InR^ex15, dock⁰⁴⁷²³ has medulla phenotype

(Song et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

One copy of InR^ex15 suppresses the R8 photoreceptor phenotype seen when gogo^Scer\UAS.T1 is expressed under the control of Scer\GAL4^GMR.PF. 12% of R8 axons form blob-like structures at the M1 layer.

(Mann et al., 2012)

dock⁰⁴⁷²³/+ ; InR^ex15/+ double heterozygotes show defects in photoreceptor axon projections in the medulla; gaps in the R7 terminal array and uninnervated areas are seen. These defects are seen in larvae and adults. dock¹³⁴²¹/+ ; InR^ex15/+ double heterozygotes show defects in photoreceptor axon projections in the medulla; gaps in the R7 terminal array and uninnervated areas are seen. These defects are seen in larvae and adults. No obvious defects in photoreceptor axon projections in the medulla are seen in chico¹/+ ; InR^ex15/+ double heterozygous adults.

(Song et al., 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

DInR^ex15

(Mikeladze-Dvali et al., 2005)

InR^ex15

(Musashe et al., 2016, Yu et al., 2009)

dinr^ex15

(Li et al., 2014, Mann et al., 2012, Song et al., 2003)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

Open Close