FlyBase Allele Report: Dmel\dock[04723]

General Information

Symbol

Dmel\dock⁰⁴⁷²³

Species

D. melanogaster

Name

FlyBase ID

FBal0008069

Feature type

allele

Associated gene

Dmel\dock

Associated Insertion(s)

P{PZ}dock⁰⁴⁷²³

Carried in Construct

Also Known As

dock^P1, l(2)04723

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - genetic evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Garrity et al., 1996)

Mutagen

P-element activity

(Garrity et al., 1996)

Progenitor genotype

Associated Insertion(s)

P{PZ}dock⁰⁴⁷²³

Cytology

Description

P{PZ} insertion in intron 1.

(Schnorr et al., 2001)

P{PZ} insertion in intron 1 of the CT42218 and CT12313 transcripts of dock, 798bp and 827bp downstream of the 5' end of the transcripts respectively.

(Misra, 2000.8.25)

P{PZ} insertion 18bp downstream of the first exon-intron boundary.

(Garrity et al., 1996)

Allele components

Component

Use(s)

Inserted element

P{PZ}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2L:826,525..826,525 [+]

(Dionne et al., 2018, Rudrapatna et al., 2014, Goto et al., 2011, MacMullin and Jacobs, 2006, Schnorr et al., 2001, Misra, 2000.8.25, Spradling et al., 1999, Garrity et al., 1996, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(Ang et al., 2003)

abnormal neuroanatomy | cell non-autonomous | somatic clone

(Ang et al., 2003)

abnormal neuroanatomy | embryonic stage

(Kamiyama et al., 2015)

abnormal neuroanatomy | embryonic stage | recessive

(Desai et al., 1999)

abnormal neuroanatomy | pupal stage

(Ang et al., 2003)

abnormal neuroanatomy | somatic clone

(Song et al., 2003)

abnormal size | oogenesis, with Scer\GAL4^{VP16.nanos.UTR}, Scer\GAL4^VP16.otu, Scer\GAL4^nanos.PG, dock^GL01519

(Stark et al., 2021)

decreased size | germline clone | oogenesis

(Stark et al., 2021)

decreased size | maternal effect

(Stark et al., 2021)

decreased size | maternal effect, with Scer\GAL4^{VP16.nanos.UTR}, Scer\GAL4^VP16.otu, Scer\GAL4^nanos.PG, dock^GL01519

(Stark et al., 2021)

lethal | embryonic stage | maternal effect | recessive

(Desai et al., 1999)

lethal | pupal stage | recessive

(Desai et al., 1999)

lethal | recessive

(Spradling et al., 1999)

lethal - all die before end of pupal stage | recessive

(Garrity et al., 1996)

short lived

(Garrity et al., 1996)

some die during embryonic stage | maternal effect, with Scer\GAL4^{VP16.nanos.UTR}, Scer\GAL4^VP16.otu, Scer\GAL4^nanos.PG, dock^GL01519

(Stark et al., 2021)

some die during pupal stage | recessive

(Garrity et al., 1996)

uncoordinated | recessive

(Garrity et al., 1996)

Phenotype Manifest In

adult antennal nerve | P-stage

(Ang et al., 2003)

antennal lobe

(Ang et al., 2003)

antennal lobe & neuropil

(Ang et al., 2003)

antennal lobe | cell non-autonomous | somatic clone

(Ang et al., 2003)

antennal lobe glomerulus | P-stage | ectopic

(Ang et al., 2003)

antennal lobe glomerulus DM2

(Ang et al., 2003)

antennal lobe glomerulus DM3

(Ang et al., 2003)

Bolwig nerve

(Schmucker et al., 2000)

Bolwig nerve (with dock¹³⁴²¹)

(Schmucker et al., 2000)

dendrite | embryonic stage

(Kamiyama et al., 2015)

egg | maternal effect

(Stark et al., 2021)

egg | maternal effect, with Scer\GAL4^{VP16.nanos.UTR}, Scer\GAL4^VP16.otu, Scer\GAL4^nanos.PG, dock^GL01519

(Stark et al., 2021)

embryonic/larval optic lobe | somatic clone

(Song et al., 2003)

embryonic/larval optic stalk

(Garrity et al., 1996)

eye photoreceptor cell & growth cone

(Ruan et al., 1999)

glial cell & antennal lobe

(Ang et al., 2003)

lamina

(Ruan et al., 1999)

lamina plexus

(Garrity et al., 1996)

larval DA1 motor neuron | embryonic stage

(Kamiyama et al., 2015)

larval inner optic anlage

(Garrity et al., 1996)

larval longitudinal connective

(Fan et al., 2003)

larval MP1 neuron

(Fan et al., 2003)

larval outer optic anlage

(Garrity et al., 1996)

lobula

(Garrity et al., 1996)

medulla

(Su et al., 2000, Ruan et al., 1999, Garrity et al., 1996)

medulla | somatic clone

(Song et al., 2003, Su et al., 2000, Garrity et al., 1996)

neuron & antennal lobe

(Ang et al., 2003)

neuron | somatic clone

(Garrity et al., 1996)

nurse cell ring canal, with Scer\GAL4^{VP16.nanos.UTR}, Scer\GAL4^VP16.otu, Scer\GAL4^nanos.PG, dock^GL01519

(Stark et al., 2021)

nurse cell ring canal | germline clone

(Stark et al., 2021)

pCC neuron

(Fan et al., 2003)

photoreceptor & axon

(Su et al., 2000)

photoreceptor & axon | somatic clone

(Su et al., 2000)

photoreceptor cell & axon

(Garrity et al., 1996)

photoreceptor cell & axon (with dock⁴)

(Newsome et al., 2000)

photoreceptor cell R1

(Rao and Zipursky, 1998)

photoreceptor cell R1 & axon

(Ruan et al., 1999)

photoreceptor cell R2

(Rao and Zipursky, 1998)

photoreceptor cell R2 & axon

(Ruan et al., 1999)

photoreceptor cell R3

(Rao and Zipursky, 1998)

photoreceptor cell R3 & axon

(Ruan et al., 1999)

photoreceptor cell R4

(Rao and Zipursky, 1998)

photoreceptor cell R4 & axon

(Ruan et al., 1999)

photoreceptor cell R5

(Rao and Zipursky, 1998)

photoreceptor cell R5 & axon

(Ruan et al., 1999)

photoreceptor cell R6

(Rao and Zipursky, 1998)

photoreceptor cell R6 & axon

(Ruan et al., 1999)

photoreceptor cell R7 & axon

(Su et al., 2000)

photoreceptor cell R7 & axon | somatic clone

(Su et al., 2000)

photoreceptor neuron | somatic clone

(Garrity et al., 1996)

RP3 neuron & synapse

(Desai et al., 1999)

Detailed Description

Statement

Reference

dock⁰⁴⁷²³ homozygous embryos show defects in dendritogenesis in the embryonic aCC motoneurons (misplacement of primary branches) compared to controls.

(Kamiyama et al., 2015)

The muscle pattern appears similar to wild type in mutant embryos.

(Kaipa et al., 2013)

dock⁰⁴⁷²³/+ mutant third instar larval eye discs do not show disrupted axon targeting from photoreceptor neurons to the brain optic lobes.

(Shcherbata et al., 2007)

The initial stages of mesoderm spreading during mesoderm morphogenesis are normal in mutant embryos.

(Wilson et al., 2005)

In dock⁰⁴⁷²³ homozygous adults the antennal lobes are small and mis-shapen compared to wild-type, and have amorphous neuropil. Antennal glomeruli DM2 and DM3 are severely mis-shapen or split into smaller structures that are scattered randomly around the antennal lobe. The integrity and position of VA11m is unaffected, but it is enlarged and extends into the domains of surrounding glomeruli, in most cases completely engulfing the adjacent VA1d. Projection neurons and glial cells differentiate normally in antennal lobes of the mutants, but dendritic arborization of the projection neurons is more diffuse than in wild-type, and the number of glial processes is somewhat reduced. The development of neurons within the antennae appears normal. When somatic clones of dock⁰⁴⁷²³ are induced in the eye-antennal disc, but not the brain (using Scer\FLP1^ey.PN), the antennal lobes are severely mis-shapen and aglomerular, and olfactory neuron axons terminate in ectopic locations. In dock⁰⁴⁷²³ homozygous pupae 30 hours after puparium formation (hAPF) the pattern of olfactory neuron projections from the antennae is normal. However, once in the antennal lobe, the axonal trajectories are clearly abnormal: instead of forming characteristic tracks, the fibers interweave to form a dense mat. Occasionally these axons leave the antennal lobe, and instead extend aberrantly into dorsal brain regions. Most axonal branches in the antennal lobe fail to reach their destination, instead terminating in ectopic mis-shapen glomeruli. Occasionally extra axon branches are seen, but they are short and not associated with ectopic glomeruli.

(Ang et al., 2003)

Mutant embryos that lack both maternal and zygotic dock, exhibit commissures that are generally thicker than wild-type, while longitudinals are reduced - many axons are seen to inappropriately cross the midline. An average of 70% of segments exhibit defects, and average of 7.7 defects are seen animal. 18% of embryos also exhibit defects in pCC/MP1.

(Fan et al., 2003)

In mosaic larvae in which homozygous clones have been induced in the eye, photoreceptor cell axons fail to target the optic lobe properly; gaps and clumps of axons are seen. The pattern of R7 and R8 projections in the medulla shows defects in mosaic adults in which homozygous clones have been induced in the eye; crossing of fibres, uninnervated regions and gaps in the R7 layer are seen. Heterozygotes have normal photoreceptor cell projections in the medulla.

(Song et al., 2003)

When mutant somatic clones are made in the border cells no effect is seen.

(Duchek et al., 2001)

14% of dock⁴/dock⁰⁴⁷²³ animals show defects in photoreceptor axon projection, having a "medulla bypass" phenotype.

(Newsome et al., 2000)

About 5% of heterozygotes exhibit some Bolwig's nerve targeting defects. In dock⁰⁴⁷²³/dock¹³⁴²¹ embryos, either the entire Bolwig's Nerve, or a subset of its axons project to ectopic positions. These defects have over a 90% penetrance.

(Schmucker et al., 2000)

The removal of dock⁰⁴⁷²³ function in the eye by making clones in a Minute background causes the same phenotype as homozygosity for dock⁰⁴⁷²³. The R7 and R8 axons in dock⁰⁴⁷²³ mutants lack expanded growth cones and fail to form an even array in the medulla.

(Su et al., 2000)

Mutant embryos show a variable absence of the synapse between RP3 and muscles 7 and 6. Outgrowth of RP3 from the CNS is normal. Synapse formation eventually occurs, but is delayed. No ectopic synapses occur. Maternal loss of dock expression enhances the CNS longitudinal axon defects, but not the RP3 synapse formation delay.

(Desai et al., 1999)

Many R1-R6 photoreceptor cell axons migrate ectopically into the medulla in homozygous larvae, passing their normal target (the lamina), generating gaps in the lamina R1-R6 termination site. Fasciculation and growth cone morphology of the photoreceptor cell axons is also altered. Abnormal large axon bundles are seen in both the lamina and medulla. The phenotype is completely penetrant.

(Ruan et al., 1999)

R cell projections in both the lamina and medulla are disorganised. Large axon bundles form: bundles contain R1-R6 neurons that fail to terminate in the lamina.

(Rao and Zipursky, 1998)

Some homozygotes survive to adulthood. These flies are sluggish and uncoordinated, dying within a few days after eclosion. Homozygous third instar larvae exhibit defects in receptor cell fasciculation, targeting and retinotopy. The plexus of receptor cell terminals in the lamina is uneven. Bundles do project into the medulla where they establish an uneven array of terminals. Grouping of axons in the optic stalk is also aberrant. The pattern of proliferation of optic lobe neuroblasts and lamina precursors is indistinguishable from wild type. Lamina and neurons are disorganised, this is a likely consequence of defects in receptor cell innervation rather than an intrinsic defect in neurons or glia. Structure of the medulla neuropile is abnormal. Mosaic heads reveal that projections of mutant fibres in the medulla terminal field are abnormal, gaps are present in the R7 terminal field and fibres cross between columns. Some R1-R6 axons underlying mutant patches project into the medulla. Most ommatidia in mosaic patches are indistinguishable from wild type. A small number of receptor cells are missing, this may reflect a weak defect in cell survival due to abnormal innervation.

(Garrity et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

dock⁰⁴⁷²³ has decreased size | maternal effect phenotype, enhanceable by Scer\GAL4^nanos.PG/Arpc2^GL01469

(Stark et al., 2021)

dock⁰⁴⁷²³ has abnormal neuroanatomy phenotype, enhanceable by sli²

(Stevens and Jacobs, 2002)

Enhancer of

Statement

Reference

dock[+]/dock⁰⁴⁷²³ is an enhancer of decreased size | maternal effect phenotype of Arpc2^GL01469, Scer\GAL4^nanos.PG

(Stark et al., 2021)

dock⁰⁴⁷²³ is an enhancer of abnormal neuroanatomy | embryonic stage phenotype of ckn^C.Δ750-806

(Weng et al., 2011)

dock⁰⁴⁷²³ is an enhancer of abnormal neuroanatomy phenotype of robo1⁵, sli¹

(Fan et al., 2003)

dock⁰⁴⁷²³ is an enhancer of abnormal neuroanatomy phenotype of sli²

(Stevens and Jacobs, 2002)

NOT Enhancer of

Statement

Reference

dock[+]/dock⁰⁴⁷²³ is a non-enhancer of decreased size | maternal effect phenotype of Scer\GAL4^nanos.PG, msn^HMJ02084

(Stark et al., 2021)

dock⁰⁴⁷²³ is a non-enhancer of visible phenotype of Ret^MEN2B.GMR

(Read et al., 2005)

dock⁰⁴⁷²³ is a non-enhancer of visible phenotype of Scer\GAL4^GMR.PF, btl^λ.UAS, stumps^UAS.Tag:FLAG

(Zhu et al., 2005)

NOT Suppressor of

Statement

Reference

dock⁰⁴⁷²³ is a non-suppressor of visible phenotype of Ret^MEN2B.GMR

(Read et al., 2005)

dock⁰⁴⁷²³ is a non-suppressor of visible phenotype of Scer\GAL4^GMR.PF, btl^λ.UAS, stumps^UAS.Tag:FLAG

(Zhu et al., 2005)

Other

Statement

Reference

Dscam1²¹/Dscam1[+], dock⁰⁴⁷²³ has abnormal neuroanatomy | embryonic stage phenotype

(Kamiyama et al., 2015)

Csk^GD9345, Scer\GAL4^ptc-559.1, dock[+]/dock⁰⁴⁷²³ has abnormal cell migration phenotype

(Rudrapatna et al., 2014)

Csk^GD9345, dock⁰⁴⁷²³ has lethal phenotype

(Rudrapatna et al., 2014)

Dg³²³, dock[+]/dock⁰⁴⁷²³ has abnormal neuroanatomy | third instar larval stage phenotype

(Shcherbata et al., 2007)

InR^ex15, dock⁰⁴⁷²³ has abnormal neuroanatomy phenotype

(Song et al., 2003)

InR[+]/InR^ex15, dock⁰⁴⁷²³ has abnormal neuroanatomy phenotype

(Song et al., 2003)

Phenotype Manifest In

Enhanced by

Statement

Reference

dock⁰⁴⁷²³ has egg | maternal effect phenotype, enhanceable by Scer\GAL4^nanos.PG/Arpc2^GL01469

(Stark et al., 2021)

dock⁰⁴⁷²³ has fascicle phenotype, enhanceable by sli²

(Stevens and Jacobs, 2002)

dock⁴/dock⁰⁴⁷²³ has phenotype, enhanceable by trio⁸/trio[+]

(Newsome et al., 2000)

dock⁴/dock⁰⁴⁷²³ has photoreceptor cell & axon phenotype, enhanceable by trio⁸/trio[+]

(Newsome et al., 2000)

dock⁴/dock⁰⁴⁷²³ has phenotype, enhanceable by trio⁴/trio[+]

(Newsome et al., 2000)

dock⁴/dock⁰⁴⁷²³ has photoreceptor cell & axon phenotype, enhanceable by trio⁴/trio[+]

(Newsome et al., 2000)

dock⁰⁴⁷²³ has photoreceptor & axon phenotype, enhanceable by msn¹⁰²

(Su et al., 2000)

NOT Enhanced by

Statement

Reference

dock⁰⁴⁷²³ has phenotype, non-enhanceable by lbm^Y13

(Desai et al., 1999)

Suppressed by

Statement

Reference

dock⁰⁴⁷²³ has eye photoreceptor cell & axon phenotype, suppressible by msn^EP549/Scer\GAL4^GMR.PF

(Ruan et al., 1999)

dock⁰⁴⁷²³ has eye photoreceptor cell & growth cone phenotype, suppressible by msn^EP549/Scer\GAL4^GMR.PF

(Ruan et al., 1999)

dock⁰⁴⁷²³ has phenotype, suppressible by Hsap\NCK1^UAS.cRa/Scer\GAL4^elav.PLu

(Rao and Zipursky, 1998)

NOT suppressed by

Statement

Reference

dock⁰⁴⁷²³ has photoreceptor & axon phenotype, non-suppressible by msn^{F.UAS.Tag:M(Far-Unk)}/Scer\GAL4^69B

(Su et al., 2000)

dock⁰⁴⁷²³ has photoreceptor & axon phenotype, non-suppressible by Scer\GAL4^elav-C155/msn^{F.UAS.Tag:M(Far-Unk)}

(Su et al., 2000)

dock⁰⁴⁷²³ has phenotype, non-suppressible by lbm^Y13

(Desai et al., 1999)

Enhancer of

Statement

Reference

dock[+]/dock⁰⁴⁷²³ is an enhancer of egg | maternal effect phenotype of Arpc2^GL01469, Scer\GAL4^nanos.PG

(Stark et al., 2021)

dock⁰⁴⁷²³ is an enhancer of embryonic myoblast phenotype of Vrp1^f06715

(Kaipa et al., 2013)

dock[+]/dock⁰⁴⁷²³ is an enhancer of embryonic myoblast phenotype of sns^4.3

(Kaipa et al., 2013)

dock⁰⁴⁷²³/dock⁰⁴⁷²³ is an enhancer of embryonic myoblast phenotype of sns^4.3

(Kaipa et al., 2013)

dock⁰⁴⁷²³ is an enhancer of larval intersegmental nerve branch ISNb of A1-7 | embryonic stage phenotype of ckn^C.Δ750-806

(Weng et al., 2011)

dock⁰⁴⁷²³ is an enhancer of larval MP1 neuron phenotype of robo1⁵, sli¹

(Fan et al., 2003)

dock⁰⁴⁷²³ is an enhancer of larval longitudinal connective phenotype of robo1⁵, sli¹

(Fan et al., 2003)

dock⁰⁴⁷²³ is an enhancer of pCC neuron phenotype of robo1⁵, sli¹

(Fan et al., 2003)

dock⁰⁴⁷²³ is an enhancer of fascicle phenotype of sli²

(Stevens and Jacobs, 2002)

dock[+]/dock⁰⁴⁷²³ is an enhancer of dorsal appendage phenotype of Ras85D^ix12a

(Schnorr et al., 2001)

NOT Enhancer of

Statement

Reference

dock[+]/dock⁰⁴⁷²³ is a non-enhancer of egg | maternal effect phenotype of Scer\GAL4^nanos.PG, msn^HMJ02084

(Stark et al., 2021)

dock[+]/dock⁰⁴⁷²³ is a non-enhancer of heart primordium phenotype of sli²

(MacMullin and Jacobs, 2006)

dock⁰⁴⁷²³ is a non-enhancer of eye phenotype of Ret^MEN2B.GMR

(Read et al., 2005)

dock⁰⁴⁷²³ is a non-enhancer of eye phenotype of Scer\GAL4^GMR.PF, btl^λ.UAS, stumps^UAS.Tag:FLAG

(Zhu et al., 2005)

Suppressor of

Statement

Reference

dock[+]/dock⁰⁴⁷²³ is a suppressor of eye phenotype of Scer\GAL4^GMR.PF, fru^NP0021

(Goto et al., 2011)

dock⁰⁴⁷²³ is a suppressor of egg chorion phenotype of Scer\GAL4^CU1, btl::Egfr^λ.UAS

(Schnorr et al., 2001)

NOT Suppressor of

Statement

Reference

dock⁰⁴⁷²³ is a non-suppressor of eye phenotype of Ret^MEN2B.GMR

(Read et al., 2005)

dock⁰⁴⁷²³ is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PF, btl^λ.UAS, stumps^UAS.Tag:FLAG

(Zhu et al., 2005)

dock⁰⁴⁷²³ is a non-suppressor of photoreceptor & axon phenotype of Scer\GAL4^elav-C155, msn^UAS.cSa

(Su et al., 2000)

Other

Statement

Reference

Arpc2^GL01469, Scer\GAL4^nanos.PG, dock[+]/dock⁰⁴⁷²³ has nurse cell ring canal phenotype

(Stark et al., 2021)

Dscam1²¹/Dscam1[+], dock⁰⁴⁷²³ has dendrite | embryonic stage phenotype

(Kamiyama et al., 2015)

Dscam1²¹/Dscam1[+], dock⁰⁴⁷²³ has larval DA1 motor neuron | embryonic stage phenotype

(Kamiyama et al., 2015)

Csk^GD9345, Scer\GAL4^ptc-559.1, dock[+]/dock⁰⁴⁷²³ has wing disc phenotype

(Rudrapatna et al., 2014)

dock⁰⁴⁷²³, hbs⁴⁵⁹ has embryonic myoblast phenotype

(Kaipa et al., 2013)

Scer\GAL4^Mef2.PR, dock⁰⁴⁷²³, kirre^VDRC.cUa has embryonic myoblast phenotype

(Kaipa et al., 2013)

ckn^C.Δ750-806, dock⁰⁴⁷²³ has larval intersegmental nerve branch ISNd of A1-7 | embryonic stage phenotype

(Weng et al., 2011)

ckn^C.Δ750-806, dock⁰⁴⁷²³ has lateral longitudinal fascicle | embryonic stage phenotype

(Weng et al., 2011)

ckn^C.Δ750-806, dock⁰⁴⁷²³ has intermediate longitudinal fascicle | embryonic stage phenotype

(Weng et al., 2011)

Dg³²³, dock[+]/dock⁰⁴⁷²³ has eye disc | third instar larval stage phenotype

(Shcherbata et al., 2007)

Dg³²³, dock[+]/dock⁰⁴⁷²³ has eye photoreceptor cell | third instar larval stage phenotype

(Shcherbata et al., 2007)

Dg³²³, dock[+]/dock⁰⁴⁷²³ has lamina plexus | third instar larval stage phenotype

(Shcherbata et al., 2007)

InR^ex15, dock⁰⁴⁷²³ has medulla anlage phenotype

(Song et al., 2003)

InR^ex15, dock⁰⁴⁷²³ has medulla phenotype

(Song et al., 2003)

InR[+]/InR^ex15, dock⁰⁴⁷²³ has medulla anlage phenotype

(Song et al., 2003)

InR[+]/InR^ex15, dock⁰⁴⁷²³ has medulla phenotype

(Song et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

dock⁰⁴⁷²³;Dscam1²¹ double heterozygous mutants display defects in dendritogenesis in the embryonic aCC motoneurons (decreased number of dendritic tips), which are not seen in either of the single heterozygotes.

(Kamiyama et al., 2015)

A dock⁰⁴⁷²³ heterozygous mutant background modifies the actin remodelling and subsequent basolateral invasion of epithelial cells seen in flies expressing Csk^GD9345 in a stripe of cells at the anterior/posterior boundary of the larval wing disc under the control of Scer\GAL4^ptc-559.1.

(Rudrapatna et al., 2014)

dock⁰⁴⁷²³ drk^e0A double mutant embryos do not show defects in myoblast fusion.

dock⁰⁴⁷²³ hbs⁴⁵⁹ double mutant embryos have severe defects in myoblast fusion.

The number of unfused myoblasts in sns^4.3 embryos is enhanced if they are either heterozygous or homozygous for dock⁰⁴⁷²³.

Expression of kirre^VDRC.cUa under the control of Scer\GAL4^Mef2.PR in a dock⁰⁴⁷²³ background results in severe myoblast fusion defects in embryos.

The muscle pattern of rst⁶ dock⁰⁴⁷²³ embryos is similar to that of rst⁶ single mutants.

(Kaipa et al., 2013)

A dock⁰⁴⁷²³ background suppresses the rough eye phenotype related to fru isoform A, found upon expression of fru^NP0021 under the control of Scer\GAL4^GMR.PF.

(Goto et al., 2011)

dock⁰⁴⁷²³ ckn^C.Δ750-806 double homozygotes exhibit delayed 'immature' ISNb axons in 59% of hemisegments. Motor axons in the affected nerves are loosely organised with multiple projections and resemble wild-type axons at earlier stages. Furthermore, the ISNd branch is frequently absent or reduced in size. Examination of the ISNb/d choice point reveals defects in ISNb/d branch segregation. The lateral two longitudinal Fas2-positive fascicles are poorly fasciculated and discontinuous in these double mutants.

(Weng et al., 2011)

dock⁰⁴⁷²³/+; Dys^8-2/+ double heterozygous mutant third instar larval eye discs do not show disrupted axon targeting from photoreceptor neurons to the brain optic lobes.

dock⁰⁴⁷²³/+; Df(3R)Dl-X43/+ double heterozygous mutant third instar larval eye discs do not show disrupted axon targeting from photoreceptor neurons to the brain optic lobes.

Dg³²³/dock⁰⁴⁷²³ double heterozygous mutant third instar larval eye discs show disrupted axon targeting from photoreceptor neurons to the brain optic lobes.

(Shcherbata et al., 2007)

dock⁰⁴⁷²³/+, sli²/+ embryos do not show defects in heart formation.

(MacMullin and Jacobs, 2006)

The antennal lobes of dock⁰⁴⁷²³/+; Pak⁴/+ animals exhibit normal axon trajectories and glomerular subdivisions.

(Ang et al., 2003)

Heterozygous dock⁰⁴⁷²³ enhances the longitudinal axon guidance and pCC/MP1 defects seen in transheterozygous sli¹, robo⁵ mutants. An average of 7.4 defects are seen per animal. 67% of segments (calculated as number of defects/segments) show defects, and 72% of embryos show defects in pCC/MP1.

(Fan et al., 2003)

dock⁰⁴⁷²³/+ ; InR^ex15/+ double heterozygotes show defects in photoreceptor axon projections in the medulla; gaps in the R7 terminal array and uninnervated areas are seen. These defects are seen in larvae and adults.

(Song et al., 2003)

Embryos with a single copy of sli² and dock⁰⁴⁷²³ have midline guidance errors in 77% of embryonic segments, sometimes involving all axon fascicles (as assayed with Fas2).

(Stevens and Jacobs, 2002)

Moderate dominant enhancer of the Ras85D^ix12a eggshell phenotype; 31-40% of dorsal appendages are wild type.

(Schnorr et al., 2001)

More than 80% of dock⁴/dock⁰⁴⁷²³ animals which are also heterozygous for either trio⁴ or trio⁸ show defects in photoreceptor axon projection, having a "medulla bypass" phenotype.

(Newsome et al., 2000)

The dock⁰⁴⁷²³ phenotype is identical to that of lbm^Y13. Double mutants show no enhanced phenotype compared to that of the single mutants.

(Desai et al., 1999)

The phenotype is largely suppressed by msn^EP549 expressed under the control of Scer\GAL4^GMR.PF; the number of photoreceptor cell axons in the medulla is dramatically reduced. The premature termination of many photoreceptor cell growth cones within the optic stalk is also seen in these larvae (this phenotype is not seen in larvae expressing msn^EP549 under the control of Scer\GAL4^GMR.PF in a wild-type background).

(Ruan et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

dock^k13421

(BDGP Project Members, 1994-1999)

dock^k16610

(BDGP Project Members, 1994-1999)

Rescued by

dock⁰⁴⁷²³ is rescued by dock^{UAS.SNAPm-tag}/Scer\GAL4^eve.RN2

(Kamiyama et al., 2015)

dock¹³⁴²¹/dock⁰⁴⁷²³ is rescued by dock^GMR.PG

(Schmucker et al., 2000)

dock⁰⁴⁷²³ is rescued by Scer\GAL4^elav.PLu/dock^UAS.cRa

(Desai et al., 1999)

dock⁰⁴⁷²³ is rescued by Scer\GAL4^elav.PLu/dock^UAS.cRa

(Rao and Zipursky, 1998)

dock⁰⁴⁷²³ is rescued by dock^W225K.UAS/Scer\GAL4^elav.PLu

(Rao and Zipursky, 1998)

dock⁰⁴⁷²³ is rescued by dock^W48K.UAS/Scer\GAL4^elav.PLu

(Rao and Zipursky, 1998)

Partially rescued by

dock⁰⁴⁷²³ is partially rescued by dock^W151K.UAS/Scer\GAL4^SG18.1

(Ang et al., 2003)

dock⁰⁴⁷²³ is partially rescued by dock^W225K.UAS/Scer\GAL4^SG18.1

(Ang et al., 2003)

dock⁰⁴⁷²³ is partially rescued by Scer\GAL4^SG18.1/dock^UAS.cRa

(Ang et al., 2003)

dock⁰⁴⁷²³ is partially rescued by Scer\GAL4^SG18.1/dock^R336Q.UAS

(Ang et al., 2003)

dock⁰⁴⁷²³ is partially rescued by dock^{W48K.W225K.UAS}/Scer\GAL4^elav.PLu

(Rao and Zipursky, 1998)

dock⁰⁴⁷²³ is partially rescued by Scer\GAL4^elav.PLu/dock^R336Q.UAS

(Rao and Zipursky, 1998)

dock⁰⁴⁷²³ is partially rescued by dock^ΔSH2.UAS/Scer\GAL4^elav.PLu

(Rao and Zipursky, 1998)

Not rescued by

dock⁰⁴⁷²³ is not rescued by dock^W48K.UAS/Scer\GAL4^SG18.1

(Ang et al., 2003)

dock⁰⁴⁷²³ is not rescued by dock^{W225K.R336Q.UAS}/Scer\GAL4^elav.PLu

(Rao and Zipursky, 1998)

dock⁰⁴⁷²³ is not rescued by dock^W151K.UAS/Scer\GAL4^elav.PLu

(Rao and Zipursky, 1998)

dock⁰⁴⁷²³ is not rescued by dock^{W48K.R336Q.UAS}/Scer\GAL4^elav.PLu

(Rao and Zipursky, 1998)

dock⁰⁴⁷²³ is not rescued by dock^{W48K.W225K.ΔSH2.UAS}/Scer\GAL4^elav.PLu

(Rao and Zipursky, 1998)

dock⁰⁴⁷²³ is not rescued by dock^{W48K.W151K.W225K.UAS}/Scer\GAL4^elav.PLu

(Rao and Zipursky, 1998)

dock⁰⁴⁷²³ is not rescued by Scer\GAL4^elav.PLu/dock^{W48K.W225K.R336Q.UAS}

(Rao and Zipursky, 1998)

Comments

The dendritogenesis defects (reduced number of dendritic tips, abnormal positioning of the remaining dendrites) in the embryonic aCC motoneurons characteristic for dock⁰⁴⁷²³ homozygotes are rescued by expression of dock^{Scer\UAS.T:Zzzz\SNAP-m} under the control of Scer\GAL4^eve.RN2 in the mutant background.

(Kamiyama et al., 2015)

Scer\GAL4^SG18.1; dock^Scer\UAS.cRa (gives expression in olfactory neurons, but not in the brain) rescues the development of most glomeruli in the antennal lobes of dock⁰⁴⁷²³ homozygous flies.

(Ang et al., 2003)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

11385

P{PZ}dock⁰⁴⁷²³ cn¹/CyO; ry⁵⁰⁶

Notes on Origin

Discoverer

A. Spradling.

Comments

Complements: ex⁰¹²⁷⁰. Complements: l(2)01855⁰¹⁸⁵⁵. Complements: Gsc⁰⁵³⁴¹. Complements: α-Adaptin⁰⁶⁶⁹⁴. Complements: capt⁰⁶⁹⁵⁵. Complements: S⁰⁷⁰⁵⁶. Complements: dbe^k00108. Complements: dbe^k05428. Complements: dbe^k05447. Complements: dbe^k06708.

(BDGP Project Members, 1994-1999)

Precise excision of the P{PZ} element reverts both the lethality and the receptor cell connectivity defects.

(Garrity et al., 1996)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

Dock⁰⁴⁷²³

(Duchek et al., 2001)

(Newsome et al., 2000)

dock⁰⁴⁷²³

(Stark et al., 2021, Dionne et al., 2018, Rudrapatna et al., 2014, Kaipa et al., 2013, Vanderploeg et al., 2012, Goto et al., 2011, Zmojdzian et al., 2008, MacMullin and Jacobs, 2006)

dock^P04723

(Zhu et al., 2005)

dock^P1

(Kamiyama et al., 2015, Sekine et al., 2013, Knox et al., 2011, Shcherbata et al., 2007, Wilson et al., 2005, Albin and Davis, 2004, Ang et al., 2003, Fan et al., 2003, Song et al., 2003, Schmucker et al., 2000, Su et al., 2000, Desai et al., 1999, Ruan et al., 1999, Rao and Zipursky, 1998, Garrity et al., 1996)

dock^P

(Weng et al., 2011)

dock^PZ4723

(Shin and Diantonio, 2011)

dock^mat

(Fan et al., 2003)

l(2)04723

(Schnorr et al., 2001, Misra, 2000.8.25, Spradling et al., 1999, Chan et al., 1998)

Name Synonyms

Secondary FlyBase IDs

References (37)

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