FB2024_03 , released June 25, 2024
Allele: Dmel\msnHMJ02084
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General Information
Symbol
Dmel\msnHMJ02084
Species
D. melanogaster
Name
FlyBase ID
FBal0281360
Feature type
allele
Associated gene
Dmel\msn
Associated Insertion(s)
Carried in Construct
P{TRiP.HMJ02084}
Also Known As
UAS-msn-RNAi, UAS-msn RNAi
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Ni et al., 2010.12.1)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Ni et al., 2010.12.1)
Mutagen
in vitro construct
(Ni et al., 2010.12.1)
Progenitor genotype
Carried in construct
P{TRiP.HMJ02084}
Cytology
Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-HMJ02084
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  tauopathy
      modeled by Hsap\MAPTUAS.cWa
      (Bernstein et al., 2016)
      modeled by Hsap\MAPTV337M.UAS
      (Bernstein et al., 2016)
      modeled by Hsap\MAPTR406W.UAS
      (Bernstein et al., 2016)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of msnHMJ02084 under the control of Scer\GAL4ptc.PU does not induce apoptosis in the ptc-domain of the third instar larval wing disc, as compared to controls.

      (Ko et al., 2016)

      Females heterozygous for msnHMJ02084 and Scer\GAL4mat.αTub67C.T:Hsim\VP16 crossed to msnHMJ02084 males results in: 0% hatching; egg/embryonic phenotype: "all brown, u-shaped, anterior head defects, twisted"; maternal effect.

      (Sopko et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhanced by
      Statement
      Reference

      Scer\GAL4nanos.PG, msnHMJ02084 has decreased size | maternal effect phenotype, non-enhanceable by dock[+]/dock04723

      (Stark et al., 2021)
      NOT Suppressor of
      Phenotype Manifest In
      NOT Enhanced by
      Statement
      Reference

      Scer\GAL4nanos.PG, msnHMJ02084 has egg | maternal effect phenotype, non-enhanceable by dock[+]/dock04723

      (Stark et al., 2021)
      NOT Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The co-expression of msnHMJ02084 does not suppress the increased apoptosis and cell dispersion within the ptc-domain of the third instar larval wing disc induced by the expression of tsrdsRNA.UAS under the control of Scer\GAL4ptc.PU.

      (Ko et al., 2016)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      msnHMJ02084
      (Bernstein et al., 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (10)