FB2024_03 , released June 25, 2024
Allele: Scer\GAL4Vsx1-MzVum
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General Information
Symbol
Scer\GAL4Vsx1-MzVum
Species
S. cerevisiae
Name
FlyBase ID
FBal0150624
Feature type
allele
Associated gene
Scer\GAL4
Associated Insertion(s)
P{GawB}MzVum
Carried in Construct
Also Known As
MzVUM-Gal4, Vsx-Gal4
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{GawB}MzVum
    Cytology
    Description

    Insertion 886bp upstream of Vsx2. The insertion reflects the expression of the Vsx1 gene located approximately 33kb from the insertion site.

    (Erclik et al., 2008)
    Allele components
    Component
    Use(s)
    Inserted element
    P{GawB}
    Encoded product / tool
    GAL4
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        distribution deduced from reporter (Gal4 UAS)
        Stage
        Tissue/Position (including subcellular localization)
        Reference
        embryonic stage 11 -- 12
        visual primordium | restricted
        (Valentino and Erclik, 2022)
        embryonic stage 12 -- third instar larval stage
        larval VUM neuron
        (Landgraf et al., 2003)
        embryonic stage 13
        embryonic/larval pharynx
        (Erclik et al., 2008)
        larval outer optic anlage
        (Erclik et al., 2008)
        larval VUM motor neuron
        (Wheeler et al., 2006)
        pars intercerebralis primordium
        (Erclik et al., 2008)
        embryonic stage 13 -- 15
        embryonic outer optic lobe primordium
        (Valentino and Erclik, 2022)
        embryonic stage 13 -- 16
        pars intercerebralis primordium
        (Hwang and Rulifson, 2011)
        late embryonic stage
        pars intercerebralis primordium
        (de Velasco et al., 2007)
        embryonic stage 17
        larval VUM motor neuron
        (Wheeler et al., 2006)
        embryonic stage 17 -- third instar larval stage
        larval VUM neuron
        (Bottenberg et al., 2009)
        first instar larval stage
        larval pars intercerebralis
        (de Velasco et al., 2007)
        third instar larval stage
        ventral group vA neuron
        (Landgraf et al., 2003)
        embryonic/larval brain | restricted
        (Erclik et al., 2008, de Velasco et al., 2007)
        outer optic anlage neuroblast
        (Erclik et al., 2008)
        lamina
        (Erclik et al., 2008)
        medulla
        (Erclik et al., 2008)
        larval outer optic anlage
        (Erclik et al., 2008)
        larval insulin secreting cell of pars intercerebralis
        (de Velasco et al., 2007)
        larval pars intercerebralis
        (de Velasco et al., 2007)
        pupal stage P5 -- P6
        transmedullary neuron
        (Ngo et al., 2017)
        adult stage
        medulla
        (Erclik et al., 2008)
        adult optic lobe neuron | subset
        (Ting et al., 2011)
        transmedullary neuron Tm5b
        (Ting et al., 2011)
        adult mushroom body
        (Khan et al., 2015)
        Additional Information
        Statement
        Reference

        Drives expression in VUM neurons, neurons of the pars intercerebralis, embryonic visual and pars intercerbralis primordia, embryonic outer optic lobe primordium and larval outer optic anlage, and transmedullary neuron Tm5b.

        (FlyBase Curators, 2017)

        ScerGAL4Vsx1-MzVum drives expression in all lobes of the adult mushroom body.

        (Khan et al., 2015)

        The reporter is observed throughout the third instar larval outer optic lobe, including cells of the outer optic anlage, outer neuroblasts, lamina and medulla but not in the lobula complex or eye disc.

        (Erclik et al., 2008)

        The reporter is observed in the embryonic pharynx, pars intercerebralis, outer optic anlage, and in the adult medulla.

        (Erclik et al., 2008)

        Expression assayed at stages 9, 11, 13, and 17. Expression may be continuous between assayed stages in some tissues.

        (Wheeler et al., 2006)

        Expression is observed in VUM motorneurons from embryonic stage 12 though third instar, in See diagram in Fig 4C of FBrf0160715.

        (Landgraf et al., 2003)
         
        Marker for
        larval VUM neuron
        (Landgraf et al., 2003)
        Reflects expression of
        Vsx1
        (Erclik et al., 2008, Erclik et al., 2008, de Velasco et al., 2007)
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer

        Ito

        (Landgraf et al., 2003)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        Scer\GAL4MzVum
        Scer\GAL4Vsx1-MzVum
        Name Synonyms
        Secondary FlyBase IDs
          References (23)