FB2024_03 , released June 25, 2024
Allele: Dmel\Fas2spin
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General Information
Symbol
Dmel\Fas2spin
Species
D. melanogaster
Name
FlyBase ID
FBal0150807
Feature type
allele
Associated gene
Dmel\Fas2
Associated Insertion(s)
P{GawB}Fas2spin
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Adam et al., 2003)
Progenitor genotype
Associated Insertion(s)
P{GawB}Fas2spin
Cytology
Description

P{GawB} insertion in the Fas2 5' UTR.

(Adam et al., 2003)
Allele components
Component
Use(s)
Inserted element
P{GawB}
Encoded product / tool
GAL4
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutant adult males show a characteristic misrotation of genitalia and are sterile. The extent of genital rotation varies from about 30o to 320o (the genital plate undergoes a stereotyped 360o clockwise rotation during metamorphosis in wild-type males) with 84% of males having their genital plate in a position corresponding to a rotation of 135-225o. The males show a clear under-rotation phenotype when looping of the spermiduct is analysed. The overall morphology of the corpora allata synapse in the ring gland is abnormal in mutant larvae, showing fused terminal boutons and a reduced number of presynaptic nerve terminals.

      (Adam et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      Fas2spin has visible phenotype, suppressible by MetK17

      (Adam et al., 2003)
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      Fas2spin has male genitalia phenotype, suppressible by MetK17

      (Adam et al., 2003)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The genital rotation defects seen in Fas2spin males are completely suppressed by Rst(1)JHK17.

      (Adam et al., 2003)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Excision of the P{GawB} element can revert the mutant phenotype.

      (Adam et al., 2003)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Fas2spin
      spin
      (Flatt et al., 2005, Adam et al., 2003)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)