FB2024_03 , released June 25, 2024
Allele: Dmel\TbhUAS.cMa
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General Information
Symbol
Dmel\TbhUAS.cMa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct of Monastirioti
FlyBase ID
FBal0152163
Feature type
allele
Associated gene
Dmel\Tbh
Associated Insertion(s)
Carried in Construct
P{UAS-Tbh.M}
Also Known As
UAS-Tβh
Key Links
Transgenic product class
cDNA
(Monastirioti, 2003)
wild_type
(Monastirioti, 2003)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Monastirioti, 2003)
wild_type
(Monastirioti, 2003)
Mutagen
in vitro construct
(Monastirioti, 2003)
Progenitor genotype
Carried in construct
P{UAS-Tbh.M}
Cytology
Description

UAS regulatory sequences drive expression of a 3.0kb EcoRI fragment containing the Tbh cDNA.

(Monastirioti, 2003)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Tbh
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhancer of
      NOT Suppressor of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      TbhUAS.cMa/Scer\GAL4Tdc2.PC rescues TbhnM18

      (Zhou et al., 2012)

      TbhUAS.cMa/Scer\GAL4Tdc2.PC rescues TbhnM18

      (Koon et al., 2011)

      TbhUAS.cMa/Scer\GAL4C57 rescues TbhnM18

      (Koon et al., 2011)

      TbhUAS.cMa/Scer\GAL4Tdc2.PC rescues TbhnM18

      (Zhou et al., 2008)

      Scer\GAL80ChAT.3.3P, TbhUAS.cMa, Scer\GAL4Tdc2.PC rescues TbhnM18

      (Zhou et al., 2008)

      TbhUAS.cMa/Scer\GAL4ptc-559.1 rescues TbhnM18

      (Monastirioti, 2003)

      TbhUAS.cMa/Scer\GAL4C164 rescues TbhnM18

      (Monastirioti, 2003)
      Partially rescues

      TbhUAS.cMa/Scer\GAL4OK348 partially rescues TbhnM18

      (Monastirioti, 2003)
      Fails to rescue

      TbhUAS.cMa/Scer\GAL4Tdc1.PC fails to rescue TbhnM18

      (Zhou et al., 2008)

      TbhUAS.cMa/Scer\GAL4c309 fails to rescue TbhnM18

      (Zhou et al., 2008)

      TbhUAS.cMa/Scer\GAL4MJ286 fails to rescue TbhnM18

      (Zhou et al., 2008)

      TbhUAS.cMa/Scer\GAL4ChAT.7.4 fails to rescue TbhnM18

      (Zhou et al., 2008)

      TbhUAS.cMa/Scer\GAL479B fails to rescue TbhnM18

      (Monastirioti, 2003)

      TbhUAS.cMa/Scer\GAL4Ddc.PL fails to rescue TbhnM18

      (Monastirioti, 2003)
      Comments

      The courtship conditioning defects seen in TbhnM18 males are rescued by expression of TbhScer\UAS.cMa under the control of Scer\GAL4Tdc2.PC.

      (Zhou et al., 2012)

      Expression of TbhScer\UAS.cMa under the control of Scer\GAL4C57 rescues the increase locomotion elicited by food deprivation and the concurrent increase in neuromuscular junction synaptopods.

      Expression of TbhScer\UAS.cMa in octopaminergic neurons under the control of Scer\GAL4Tdc2.PC rescues the drop in type II boutons and terminal branches seen in TbhnM18 mutant third instar larval neuromuscular junctions.

      (Koon et al., 2011)

      Expression of TbhScer\UAS.cMa under the control of Scer\GAL4Tdc2.PC reduces the aggression deficiency that is seen in TbhnM18 males; fighting latency is shortened and the frequencies of both lunging and high-intensity fighting (holding, boxing and tussling) are increased in the rescued flies in an aggression assay. Expression of TbhScer\UAS.cMa under the control of Scer\GAL4Tdc2.PC also effectively rescues the aggression phenotype of TbhnM18 females.

      Expression of TbhScer\UAS.cMa under the control of either Scer\GAL4Tdc1.PC, Scer\GAL4c309, Scer\GAL4MJ286 or Scer\GAL4Cha.7.4 fails to rescue the reduced aggression phenotypes of TbhnM18 males.

      Expression of TbhScer\UAS.cMa under the control of Scer\GAL4Tdc2.PC in the presence of the Scer\GAL80Cha.PK repressor (which inhibits Scer\GAL4 in the Cha expression domain) rescues the reduced aggression phenotypes of TbhnM18 males.

      (Zhou et al., 2008)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      TbhScer\UAS.cMa
      TbhUAS.cMa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct of Monastirioti
      (Monastirioti, 2003)
      Secondary FlyBase IDs
        References (6)