FB2024_03 , released June 25, 2024
Allele: Dmel\PakKR.UAS
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General Information
Symbol
Dmel\PakKR.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0156107
Feature type
allele
Associated gene
Dmel\Pak
Associated Insertion(s)
Carried in Construct
P{UAS-Pak.KR}
Key Links
Transgenic product class
dominant_negative_variant
(Chen et al., 2004)
Mutagen
Nature of the Allele
Transgenic product class
dominant_negative_variant
(Chen et al., 2004)
Mutagen
in vitro construct
(Chen et al., 2004)
Progenitor genotype
Carried in construct
P{UAS-Pak.KR}
Cytology
Description

UAS regulatory sequences drive expression of a dominant negative form of Pak.

(Chen et al., 2004)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Pak
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Suppressor of
      Statement
      Reference

      PakKR.UAS, Scer\GAL4en-e16E is a non-suppressor of visible phenotype of LIMK1UAS.cCa, Scer\GAL4en-e16E

      (Chen et al., 2004)
      Phenotype Manifest In
      NOT Suppressor of
      Statement
      Reference

      PakKR.UAS, Scer\GAL4en-e16E is a non-suppressor of wing phenotype of LIMK1UAS.cCa, Scer\GAL4en-e16E

      (Chen et al., 2004)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of PakKR.Scer\UAS has very little effect on the mutant wing phenotype caused by expression of LIMK1Scer\UAS.cCa under the control of Scer\GAL4en-e16E (the % of wings with normal morphology at 18oC is 16% compared to 9% for control flies expressing LIMK1Scer\UAS.cCa under the control of Scer\GAL4en-e16E in an otherwise wild-type background).

      (Chen et al., 2004)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      PakKR.Scer\UAS
      PakKR.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)