FlyBase Allele Report: Dmel\Patronin[EY05252]

General Information

Symbol

Dmel\Patronin^EY05252

Species

D. melanogaster

Name

FlyBase ID

FBal0159077

Feature type

allele

Associated gene

Dmel\Patronin

Associated Insertion(s)

P{EPgy2}Patronin^EY05252

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - molecular evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypomorphic allele - molecular evidence

(Yang and Choi, 2021)

Mutagen

P-element activity

(Gene Disruption Project members, 2001-)

Progenitor genotype

Associated Insertion(s)

P{EPgy2}Patronin^EY05252

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{EPgy2}

misexpression element

Regulatory region(s)

UASp

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:17,535,354..17,535,354 [+]

(Gao et al., 2024, Gene Disruption Project members, 2001-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | larval stage (with Df(2R)BSC355)

(Gao et al., 2024)

decreased size | adult stage | somatic clone

(Yang and Choi, 2021)

lethal

(Yang and Choi, 2021)

visible | adult stage | somatic clone

(Yang and Choi, 2021)

Phenotype Manifest In

eye | somatic clone - tissue specific

(Yang and Choi, 2021)

follicle cell | cell non-autonomous | somatic clone

(Nashchekin et al., 2016)

follicle cell | somatic clone

(Nashchekin et al., 2016)

microtubule | larval stage (with Df(2R)BSC355)

(Gao et al., 2024)

microtubule | somatic clone

(Nashchekin et al., 2016)

neuron projection | larval stage (with Df(2R)BSC355)

(Gao et al., 2024)

NMJ bouton | decreased number | larval stage (with Df(2R)BSC355)

(Gao et al., 2024)

wing | somatic clone

(Yang and Choi, 2021)

Detailed Description

Statement

Reference

Patronin^EY05252 mutant follicle cell clones contain many fewer microtubules than their heterozygous neighbors and their presence in the tissue disrupts the follicle cell epithelial monolayer.

(Nashchekin et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Patronin^EY05252/Df(2R)BSC355 has abnormal neuroanatomy | larval stage phenotype, suppressible by Scer\GAL4^RapGAP1-OK6/shot^LC.UAS.GFP

(Gao et al., 2024)

NOT suppressed by

Statement

Reference

Patronin^EY05252/Df(2R)BSC355 has abnormal neuroanatomy | larval stage phenotype, non-suppressible by Klp10A^HMS00920/Scer\GAL4^RapGAP1-OK6

(Gao et al., 2024)

Phenotype Manifest In

Suppressed by

Statement

Reference

Patronin^EY05252/Df(2R)BSC355 has NMJ bouton | larval stage phenotype, suppressible by Scer\GAL4^RapGAP1-OK6/shot^LC.UAS.GFP

(Gao et al., 2024)

Patronin^EY05252/Df(2R)BSC355 has microtubule | larval stage phenotype, suppressible by Scer\GAL4^RapGAP1-OK6/shot^LC.UAS.GFP

(Gao et al., 2024)

NOT suppressed by

Statement

Reference

Patronin^EY05252/Df(2R)BSC355 has NMJ bouton | larval stage phenotype, non-suppressible by Klp10A^HMS00920/Scer\GAL4^RapGAP1-OK6

(Gao et al., 2024)

Patronin^EY05252 has follicle cell | somatic clone phenotype, non-suppressible | somatic clone by Klp10A²⁴/Klp10A²⁴

(Nashchekin et al., 2016)

Patronin^EY05252 has microtubule | somatic clone phenotype, non-suppressible | somatic clone by Klp10A²⁴/Klp10A²⁴

(Nashchekin et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

The defective microtubule organization observed in Patronin^EY05252 mutant follicle cell clones is not improved upon combination with Klp10A²⁴ in Patronin^EY05252;Klp10A²⁴ double mutant clones.

(Nashchekin et al., 2016)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Patronin^EY05252/Df(2R)BSC355 is rescued by Scer\GAL4^RapGAP1-OK6/Patronin^ΔCC.UAS

(Gao et al., 2024)

Patronin^EY05252/Df(2R)BSC355 is rescued by Patronin^UAS.Tag:HA/Scer\GAL4^RapGAP1-OK6

(Gao et al., 2024)

Patronin^EY05252 is rescued by Patronin^{Ubi-p63E.A.GFP}

(Yang and Choi, 2021)