Gug519/Gug[+] is an enhancer | maternal effect of partially lethal | heat sensitive phenotype of ftz5/ftz13
Gug519/Gug[+] is an enhancer of embryonic segment phenotype of ftz5/ftz13
Gug519/Gug[+] is an enhancer of adult abdominal segment 4 | ectopic phenotype of trx3
Gug519/Gug[+] is an enhancer of adult abdominal segment 5 phenotype of trx3
Gug519 is a suppressor of prothoracic leg | ectopic phenotype of ScrMsc
Gug519/Gug[+] is a suppressor of mesothoracic leg phenotype of Pcl4/Pcl1
Gug519/Gug[+] is a suppressor of prothoracic leg | ectopic phenotype of Pcl4/Pcl1
Gug519 is a suppressor of mesothoracic leg phenotype of ScrMsc
Gug519 dominantly enhances the lethality of ftz5/ftz13 animals at 26.5oC (fewer animals survive to adulthood). This interaction shows a strong maternal effect and a weak zygotic effect. Gug519 dominantly enhances the segmentation defects seen in ftz5/ftz13 embryos at 27.5oC; 100% of the embryos have segment defects and 90.2% have at least 3 ftz-dependent segments affected. The mutant arista phenotype seen in AntpNs/+ adults is partially suppressed if they are also heterozygous for Gug519 (36% of flies have normal arista development). The reduction in the number of sex comb teeth on the first leg seen in Df(3R)Scr/+ males is enhanced by heterozygosity for Gug519. Gug519/+ enhances the frequency of transformation of haltere to wing seen in Df(3L)brm11/+ flies. The transformation of second leg to first leg seen in Pcl1/Pcl4 males is strongly suppressed by heterozygosity for Gug519.