FlyBase Allele Report: Dmel\Gug[3333]

General Information

Symbol

Dmel\Gug³³³³

Species

D. melanogaster

Name

FlyBase ID

FBal0176119

Feature type

allele

Associated gene

Dmel\Gug

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Kankel et al., 2004)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | somatic clone

(Kankel et al., 2004)

Phenotype Manifest In

embryonic segment | germline clone | non-rescuable maternal effect

(Kankel et al., 2004)

wing vein | ectopic | somatic clone

(Kankel et al., 2004)

wing vein | somatic clone

(Kankel et al., 2004)

Detailed Description

Statement

Reference

Embryos derived from homozygous female germline clones show ftz-like segmentation defects (even if the paternal chromosome is wild-type for Gug function). Homozygous clones in the wing result in ectopic and missing wing vein elements.

(Kankel et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Gug³³³³/Gug[+] is an enhancer | maternal effect of partially lethal | heat sensitive phenotype of ftz⁵/ftz¹³

(Kankel et al., 2004)

Gug³³³³/Gug[+] is an enhancer of visible | dominant | homeotic phenotype of trx³

(Kankel et al., 2004)

Suppressor of

Statement

Reference

Gug³³³³/Gug[+] is a suppressor of visible | homeotic phenotype of Pcl⁴/Pcl¹

(Kankel et al., 2004)

Gug³³³³/Gug[+] is a suppressor of visible | dominant phenotype of Antp^Ns

(Kankel et al., 2004)

Gug³³³³ is a suppressor of visible | homeotic phenotype of Scr^Msc

(Kankel et al., 2004)

NOT Suppressor of

Statement

Reference

Gug³³³³/Gug[+] is a non-suppressor of visible | dominant phenotype of Antp^73b

(Kankel et al., 2004)

Phenotype Manifest In

Enhancer of

Statement

Reference

Gug³³³³/Gug[+] is an enhancer of embryonic segment phenotype of ftz⁵/ftz¹³

(Kankel et al., 2004)

Gug³³³³/Gug[+] is an enhancer of adult abdominal segment 4 | ectopic phenotype of trx³

(Kankel et al., 2004)

Gug³³³³/Gug[+] is an enhancer of adult abdominal segment 5 phenotype of trx³

(Kankel et al., 2004)

Suppressor of

Statement

Reference

Gug³³³³ is a suppressor of prothoracic leg | ectopic phenotype of Scr^Msc

(Kankel et al., 2004)

Gug³³³³/Gug[+] is a suppressor of mesothoracic leg phenotype of Pcl⁴/Pcl¹

(Kankel et al., 2004)

Gug³³³³/Gug[+] is a suppressor of prothoracic leg | ectopic phenotype of Pcl⁴/Pcl¹

(Kankel et al., 2004)

Gug³³³³/Gug[+] is a suppressor of sex comb | ectopic phenotype of Pcl⁴/Pcl¹

(Kankel et al., 2004)

Gug³³³³/Gug[+] is a suppressor of arista phenotype of Antp^Ns

(Kankel et al., 2004)

Gug³³³³ is a suppressor of mesothoracic leg phenotype of Scr^Msc

(Kankel et al., 2004)

NOT Suppressor of

Statement

Reference

Gug³³³³/Gug[+] is a non-suppressor of arista phenotype of Antp^73b

(Kankel et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

Gug³³³³ dominantly enhances the lethality of ftz⁵/ftz¹³ animals at 26.5^oC (fewer animals survive to adulthood). This interaction is a maternal effect. Gug³³³³ dominantly enhances the segmentation defects seen in ftz⁵/ftz¹³ embryos at 27.5^oC; 98.7% of the embryos have segment defects and 98.0% have at least 3 ftz-dependent segments affected. The mutant arista phenotype seen in Antp^Ns/+ adults is partially suppressed if they are also heterozygous for Gug³³³³ (28% of flies have normal arista development). The reduction in the number of sex comb teeth on the first leg seen in Df(3R)Scr/+ males is enhanced by heterozygosity for Gug³³³³. Gug³³³³/+ enhances the frequency of transformation of haltere to wing seen in Df(3L)brm11/+ flies. The transformation of second leg to first leg seen in Pcl¹/Pcl⁴ males is strongly suppressed by heterozygosity for Gug³³³³.

(Kankel et al., 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Gug⁰³⁹²⁸

(Kankel et al., 2004)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Selected as: a dominant enhancer of the lethality of ftz⁵/ftz¹³ at 26.5^oC.

(Kankel et al., 2004)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Atro³³³³

(Kankel et al., 2004)

Gug³³³³

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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