FlyBase Allele Report: Dmel\Gug[1757]

General Information

Symbol

Dmel\Gug¹⁷⁵⁷

Species

D. melanogaster

Name

FlyBase ID

FBal0176121

Feature type

allele

Associated gene

Dmel\Gug

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Kankel et al., 2004)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | homeotic | recessive | somatic clone

(Kankel et al., 2004)

visible | recessive | somatic clone

(Kankel et al., 2004)

Phenotype Manifest In

adult abdominal segment 5 | somatic clone

(Kankel et al., 2004)

adult abdominal segment 6 | somatic clone

(Kankel et al., 2004)

egg | germline clone | maternal effect

(Kankel et al., 2004)

embryo | germline clone | maternal effect

(Kankel et al., 2004)

leg | cell non-autonomous | somatic clone | ventral

(Kankel et al., 2004)

Detailed Description

Statement

Reference

Most eggs laid by females with homozygous germline clones appear not to be fertilised and those that do initiate development die before cuticle formation. Homozygous somatic clones are generated in the abdomens of adult males at a frequency nearly identical to that of control clones. Mutant clones in the abdomen often cause a transformation of A5 and A6 to a more anterior segment identity. Homozygous clones in the leg often cause outgrowths from the ventral surface of the leg. These outgrowths may occur anywhere from the coxa to the tibia along the proximodistal axis, but are most common in the coxa-trochanter region. The distal-most portion of the outgrowth is always mutant for Gug, but more proximal regions of the outgrowth are usually a mix of mutant and wild-type cells, or are composed entirely of wild-type cells.

(Kankel et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Gug[+]/Gug¹⁷⁵⁷ is an enhancer of visible | dominant | homeotic phenotype of Ubx¹

(Kankel et al., 2004)

Gug[+]/Gug¹⁷⁵⁷ is an enhancer | maternal effect of partially lethal | heat sensitive phenotype of ftz⁵/ftz¹³

(Kankel et al., 2004)

Gug[+]/Gug¹⁷⁵⁷ is an enhancer of visible | dominant | homeotic phenotype of trx³

(Kankel et al., 2004)

Suppressor of

Statement

Reference

Gug[+]/Gug¹⁷⁵⁷ is a suppressor of visible | homeotic phenotype of Pcl⁴/Pcl¹

(Kankel et al., 2004)

Gug[+]/Gug¹⁷⁵⁷ is a suppressor of visible | dominant phenotype of Antp^Ns

(Kankel et al., 2004)

Gug¹⁷⁵⁷ is a suppressor of visible | homeotic phenotype of Scr^Msc

(Kankel et al., 2004)

NOT Suppressor of

Statement

Reference

Gug[+]/Gug¹⁷⁵⁷ is a non-suppressor of visible | dominant phenotype of Antp^73b

(Kankel et al., 2004)

Phenotype Manifest In

Enhancer of

Statement

Reference

Gug[+]/Gug¹⁷⁵⁷ is an enhancer of haltere phenotype of Ubx¹

(Kankel et al., 2004)

Gug[+]/Gug¹⁷⁵⁷ is an enhancer of wing margin bristle | ectopic phenotype of Ubx¹

(Kankel et al., 2004)

Gug[+]/Gug¹⁷⁵⁷ is an enhancer of wing | ectopic phenotype of Ubx¹

(Kankel et al., 2004)

Gug[+]/Gug¹⁷⁵⁷ is an enhancer of embryonic segment phenotype of ftz⁵/ftz¹³

(Kankel et al., 2004)

Gug[+]/Gug¹⁷⁵⁷ is an enhancer of adult abdominal segment 4 | ectopic phenotype of trx³

(Kankel et al., 2004)

Gug[+]/Gug¹⁷⁵⁷ is an enhancer of adult abdominal segment 5 phenotype of trx³

(Kankel et al., 2004)

Suppressor of

Statement

Reference

Gug¹⁷⁵⁷ is a suppressor of prothoracic leg | ectopic phenotype of Scr^Msc

(Kankel et al., 2004)

Gug[+]/Gug¹⁷⁵⁷ is a suppressor of mesothoracic leg phenotype of Pcl⁴/Pcl¹

(Kankel et al., 2004)

Gug[+]/Gug¹⁷⁵⁷ is a suppressor of prothoracic leg | ectopic phenotype of Pcl⁴/Pcl¹

(Kankel et al., 2004)

Gug[+]/Gug¹⁷⁵⁷ is a suppressor of sex comb | ectopic phenotype of Pcl⁴/Pcl¹

(Kankel et al., 2004)

Gug[+]/Gug¹⁷⁵⁷ is a suppressor of arista phenotype of Antp^Ns

(Kankel et al., 2004)

Gug¹⁷⁵⁷ is a suppressor of mesothoracic leg phenotype of Scr^Msc

(Kankel et al., 2004)

NOT Suppressor of

Statement

Reference

Gug[+]/Gug¹⁷⁵⁷ is a non-suppressor of arista phenotype of Antp^73b

(Kankel et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

Gug¹⁷⁵⁷ dominantly enhances the lethality of ftz⁵/ftz¹³ animals at 26.5^oC (fewer animals survive to adulthood). This interaction is a maternal effect. Gug¹⁷⁵⁷ dominantly enhances the segmentation defects seen in ftz⁵/ftz¹³ embryos at 27.5^oC; 89.7% of the embryos have segment defects and 55.1% have at least 3 ftz-dependent segments affected. Gug¹⁷⁵⁷/+ enhances the transformation of segments A5 to A4, A6 to A5 and A7 to A6 seen in Df(3R)P9/+ males. The weak transformation of haltere to wing seen in Ubx¹/+ and Df(3R)P9/+ adults is strongly enhanced by Gug¹⁷⁵⁷/+; haltere size and the number of marginal bristles are increased. The mutant arista phenotype seen in Antp^Ns/+ adults is partially suppressed if they are also heterozygous for Gug¹⁷⁵⁷ (26% of flies have normal arista development). The reduction in the number of sex comb teeth on the first leg seen in Df(3R)Scr/+ males is enhanced by heterozygosity for Gug¹⁷⁵⁷. Gug¹⁷⁵⁷/+ enhances the frequency of transformation of haltere to wing seen in Df(3L)brm11/+ flies. The transformation of second leg to first leg seen in Pcl¹/Pcl⁴ males is strongly suppressed by heterozygosity for Gug¹⁷⁵⁷.

(Kankel et al., 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Gug⁰³⁹²⁸

(Kankel et al., 2004)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Selected as: a dominant enhancer of the lethality of ftz⁵/ftz¹³ at 26.5^oC.

(Kankel et al., 2004)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Atro¹⁷⁵⁷

(Kankel et al., 2004)

Gug¹⁷⁵⁷

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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