FB2024_03 , released June 25, 2024
Allele: Dmel\Atg7RNAi.UAS
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General Information
Symbol
Dmel\Atg7RNAi.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0176389
Feature type
allele
Associated gene
Dmel\Atg7
Associated Insertion(s)
Carried in Construct
P{UAS-Atg7.RNAi}
Also Known As
Atg7-RNAi, UAS-atg7RNAi
Key Links
Transgenic product class
RNAi_reagent
(Scott et al., 2004)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Scott et al., 2004)
Mutagen
in vitro construct
(Scott et al., 2004, Scott et al., 2004)
Progenitor genotype
Carried in construct
P{UAS-Atg7.RNAi}
Cytology
Description

Inverted repeat construct, with 3'-5'.5'-3' inverted repeats whose expression is driven by UASt.

(Scott et al., 2004)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Atg7
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Adults expressing Atg7dsRNA.UAS under the control of Scer\GAL4hs.PB infected with ZIKV present an increased viral load in the head, as compared to infected controls.

      (Liu et al., 2018)

      Expression of Atg7dsRNA.Scer\UAS RNAi under the control of Scer\GAL4C57 does not cause any obvious defects in lysosomal tubular network in the sarcoplasm of third instar larval muscle.

      (Johnson et al., 2015)

      Expression of Atg7dsRNA.Scer\UAS under the control of either Scer\GAL4esg-NP5130 or Scer\GAL4Myo31DF-NP0001 results in increased intestinal stem cell proliferation in response to paraquat or Ecc15.

      (Tang et al., 2013)

      Flies expressing Atg7dsRNA.Scer\UAS under the control of Scer\GAL4Act5C.Switch.PR in the presence of RU486 show reduced lysotracker red staining of the adult midgut compared to controls in both fed and fasting flies.

      Adult expression of Atg7dsRNA.Scer\UAS under the control of Scer\GAL4Act5C.Switch.PR in the presence of RU486 has no effect on adult lifespan.

      The lifespan of flies injected with E.coli is significantly reduced by expression of Atg7dsRNA.Scer\UAS under the control of Scer\GAL4Act5C.Switch.PR in the presence of RU486. These flies show a significant increase in bacterial load compared to control flies.

      (Ren et al., 2009)

      Flies expressing Atg7dsRNA.Scer\UAS under the control of Scer\GAL4Act are more sensitive to infection by Vesicular Stomatitis Virus than control flies, and succumb to the virus.

      (Shelly et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of Atg7dsRNA.Scer\UAS is unable to suppress the rough eye phenotype and third instar larval eye disc cell death seen when Atg9Scer\UAS.T:Zzzz\FLAG is expressed under the control of Scer\GAL4GMR.PU.

      (Tang et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Atg7RNAi.UAS
      Atg7dsRNA.Scer\UAS
      Atg7dsRNA.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (12)