FB2024_03 , released June 25, 2024
Allele: Scer\GAL4c061
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General Information
Symbol
Scer\GAL4c061
Species
S. cerevisiae
Name
FlyBase ID
FBal0181629
Feature type
allele
Associated gene
Scer\GAL4
Associated Insertion(s)
P{GawB}c061
Carried in Construct
Also Known As
c061-GAL4, c061
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Rodan et al., 2002)
Progenitor genotype
Associated Insertion(s)
P{GawB}c061
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{GawB}
Encoded product / tool
GAL4
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      distribution deduced from reporter (Gal4 UAS)
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      adult stage
      adult mushroom body | restricted
      (Krashes et al., 2009)
      MB-AMP neuron of the dopaminergic PPL1 cluster
      (Liu et al., 2012)
      protocerebrum | dorsal
      (Krashes et al., 2009)
      fan-shaped body
      (Krashes et al., 2009)
      mushroom body pedunculus-medial lobe arborizing neuron 1
      (Zhang et al., 2022, Burke et al., 2012, Liu et al., 2012)
      adult neuron | subset of adult brain
      (Zhang et al., 2022)
      Additional Information
      Statement
      Reference

      Drives expression in neurons of the fan-shaped body and mushroom body, including the mushroom body pedunculus-medial lobe arborizing neuron 1 and MB-AMP neuron of the dopaminergic PPL1 cluster

      (FlyBase Curators, 2017)

      ScerGAL4c061 drives expression in two MB-MP1 and one MB-AMP neurons of the dopaminergic PPL1 cluster.

      (Liu et al., 2012)

      Using GFP reconstitution across synaptic partners (GRASP) in MB-MP1 dopaminergic neurons labelled by ScerGAL4c061 and octopaminergic neurons labelled by ScerGAL4Tdc2.PC, reveals expression of GFP in the anterior medial protocerebrum and in the mushroom body heel.

      (Burke et al., 2012)

      ScerGAL4c061 drives expression in neurons of the dorsal protocerebrum, mushroom body and fan-shaped body.

      (Krashes et al., 2009)
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Inhibition (using shi1.UAS at 33[o]C) of a subset of Scer\GAL4c061 cells (restricted using Scer\GAL80Mef2.mb247) in adults 30 min before and during testing, does not affect 3 h appetitive olfactory memory in starved adults, but does significantly increase memory in flies that are fed between training and testing, compared to controls.

      (Perisse et al., 2016)

      Inhibition of neural activity in Scer\GAL4c061-expressing neurons does not affect sensitivity to (S,Z,Z)-CH503 (a more potent stereoisomer of the gustatory sex pheromone CH503). As in wild type flies, courtship defects are seen in response to (S,Z,Z)-CH503.

      (Shankar et al., 2015)

      Thermogenetic activation (using TrpA1UAS.(B).cKa at 30[o]C) of a subset of Scer\GAL4c061 cells in adults (activation restricted using Scer\GAL80Mef2.mb247), in combination with a paired odor, results in a robust increase in 2-min aversive olfactory memory, compared to controls, and this persists for 2 hours; the increase in 2-min memory is significantly reduced when activation is restricted to a smaller subset of Scer\GAL4c061 cells using Scer\GAL80ple.PK or Scer\GAL80ChAT.3.3P.

      (Aso et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      dyscUAS.long/Scer\GAL4c061 fails to rescue dyscs168/dyscc03838

      (Jepson et al., 2012)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Scer\GAL4c061
      Name Synonyms
      Secondary FlyBase IDs
        References (22)