FB2024_03 , released June 25, 2024
Allele: Dmel\Nedd4T119FS
Open Close
General Information
Symbol
Dmel\Nedd4T119FS
Species
D. melanogaster
Name
FlyBase ID
FBal0182538
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Nature of the Allele
Allele class
Progenitor genotype
Associated Insertion(s)
Cytology
Description

Frameshift at position T119.

Amino acid alteration. In addition, the P{GSV6}Nedd4GS13178 insertion is still present on the chromosome.

Allele components
Component
Use(s)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous clones in the wing and leg discs survive without significant developmental defects.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference

Nedd4T119FS is a suppressor of visible | dominant phenotype of N264-39

Phenotype Manifest In
Enhancer of
Statement
Reference
Suppressor of
Statement
Reference

Nedd4T119FS is a suppressor of wing margin phenotype of N264-39

Additional Comments
Genetic Interactions
Statement
Reference

Heterozygosity for Nedd4T119FS enhances the wing phenotype caused by expression of two copies of Sep4Scer\UAS.cMa under the control of Scer\GAL4da.G32.

The nicked wing phenotype seen in N264-39/+ flies is suppressed by Nedd4T119FS/+.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescued by
Comments

Expression of Nedd4Scer\UAS.Long.T:Zzzz\FLAG throughout the embryo driven by Scer\GAL4Act5C.PI fails to rescue the lethality of homozygous Nedd4T119FS mutant embryos.

Expression of Nedd4Scer\UAS.Short.T:Zzzz\FLAG throughout the embryo driven by Scer\GAL4Act5C.PI partially rescues the lethality of homozygous Nedd4T119FS mutant embryos.

Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer

Selected as: a revertant of the larval lethality caused by expression of Nedd4GS13178 under the control of Scer\GAL4da.G32.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
Nedd4T119FS
dNedd4T119FS
dNedd4T121FS
Name Synonyms
Secondary FlyBase IDs
    References (6)