FlyBase Allele Report: Hsap\STK36[UAS.Δ77-98]

General Information

Symbol

Hsap\STK36^UAS.Δ77-98

Species

H. sapiens

Name

FlyBase ID

FBal0183190

Feature type

allele

Associated gene

Hsap\STK36

Associated Insertion(s)

Carried in Construct

P{UAS-Hsap\fu.Δ77-98}

Key Links

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Daoud and Blanchet-Tournier, 2005)

Progenitor genotype

Carried in construct

P{UAS-Hsap\fu.Δ77-98}

Cytology

Description

Hsap\STK36 wild-type cDNA (KIAA1278), cloned downstream of UASt regulatory sequences.

(Daoud and Blanchet-Tournier, 2005)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Hsap\STK36

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible, with Scer\GAL4^ptc-559.1

(Daoud and Blanchet-Tournier, 2005)

Phenotype Manifest In

Detailed Description

Statement

Reference

Homozygous expression of Hsap\fu^{Scer\UAS.Δ77-98} under the control of homozygous Scer\GAL4^ptc-559.1 leads to abnormalities in adult wings such as paraveins, supernumerary crossveins or a disappearance of the anterior crossvein. These wings also exhibit a posterior extension of the innervated double-row wing margin bristles, which normally terminate at the end of wing vein L3. This may be due to an anterior shift in vein 3 as the campaniform sensilla that usually sit on this vein are posterior to it and there is a significant increase in the area between veins 3 and 4 compared to wild-type.

(Daoud and Blanchet-Tournier, 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhancer of

Statement

Reference

Scer\GAL4^ptc-559.1/Hsap\STK36^UAS.Δ77-98 is an enhancer of costal vein phenotype of fu^RX2

(Daoud and Blanchet-Tournier, 2005)

Scer\GAL4^ptc-559.1/Hsap\STK36^UAS.Δ77-98 is an enhancer of discal cell phenotype of fu⁵²

(Daoud and Blanchet-Tournier, 2005)

Scer\GAL4^ptc-559.1/Hsap\STK36^UAS.Δ77-98 is an enhancer of wing basal cell 2 phenotype of fu⁵²

(Daoud and Blanchet-Tournier, 2005)

Scer\GAL4^ptc-559.1/Hsap\STK36^UAS.Δ77-98 is an enhancer of wing vein L4 phenotype of fu⁵²

(Daoud and Blanchet-Tournier, 2005)

Scer\GAL4^ptc-559.1/Hsap\STK36^UAS.Δ77-98 is an enhancer of wing vein L3 phenotype of fu⁵²

(Daoud and Blanchet-Tournier, 2005)

NOT Enhancer of

Statement

Reference

Scer\GAL4^ptc-559.1/Hsap\STK36^UAS.Δ77-98 is a non-enhancer of discal cell phenotype of fu^RX2

(Daoud and Blanchet-Tournier, 2005)

Scer\GAL4^ptc-559.1/Hsap\STK36^UAS.Δ77-98 is a non-enhancer of wing vein L3 phenotype of fu^RX2

(Daoud and Blanchet-Tournier, 2005)

Scer\GAL4^ptc-559.1/Hsap\STK36^UAS.Δ77-98 is a non-enhancer of wing vein L4 phenotype of fu^RX2

(Daoud and Blanchet-Tournier, 2005)

Scer\GAL4^ptc-559.1/Hsap\STK36^UAS.Δ77-98 is a non-enhancer of wing basal cell 2 phenotype of fu^RX2

(Daoud and Blanchet-Tournier, 2005)

Other

Statement

Reference

Hsap\STK36^UAS.Δ77-98, Scer\GAL4^ptc-559.1, fu^RX2 has costal vein phenotype

(Daoud and Blanchet-Tournier, 2005)

Additional Comments

Genetic Interactions

Statement

Reference

Hsap\fu^{Scer\UAS.Δ77-98}; Scer\GAL4^ptc-559.1 does not significantly suppress fusion of wing veins L3 and L4 seen in fu^RX2 hemizygotes, but often leads to a small overgrowth of the costa. Hsap\fu^{Scer\UAS.Δ77-98}; Scer\GAL4^ptc-559.1 enhances the partial fusion of wing veins L3 and L4 seen in fu⁵² flies.

(Daoud and Blanchet-Tournier, 2005)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Hsap\STK36^{Scer\UAS.Δ77-98}

Hsap\STK36^UAS.Δ77-98

Hsap\fu^{Scer\UAS.Δ77-98}

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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