FlyBase Allele Report: Dmel\fu[RX2]

General Information

Symbol

Dmel\fu^RX2

Species

D. melanogaster

Name

FlyBase ID

FBal0034715

Feature type

allele

Associated gene

Dmel\fu

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

X ray

Nature of the Allele

Allele class

Mutagen

X ray

(Therond et al., 1996, Preat et al., 1993)

Progenitor genotype

Cytology

Description

Defined by an 89 residue extension of the C-terminal domain due to a frameshift mutation.

(Daoud and Blanchet-Tournier, 2005)

Deletion causing frameshift at residue 748 causing deletion of the carboxy terminal 57 amino acids.

(Robbins et al., 1997)

Deletion of genomic sequences 3347-3362, only the first 748 amino acids are present followed by 89 new amino acids.

(Therond et al., 1996)

Mutation in the putative regulatory domain. Class II fu allele, affects the carboxy domain of the protein by changing the open reading frame in the 5' region.

(Preat et al., 1993)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

X:18,660,282..18,660,297 [+]

Comment:

16bp deletion

(Therond et al., 1996)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | recessive

(Daoud and Blanchet-Tournier, 2005)

Phenotype Manifest In

discal cell

(Daoud and Blanchet-Tournier, 2005)

wing basal cell 2

(Daoud and Blanchet-Tournier, 2005)

wing vein L3

(Daoud and Blanchet-Tournier, 2005)

wing vein L4

(Daoud and Blanchet-Tournier, 2005)

Detailed Description

Statement

Reference

The wings of fu^RX2 mutant flies display more or less total fusion of the LV3 and LV4 wing veins.

(Daoud and Blanchet-Tournier, 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Su(fu)^LP, fu^RX2 has lethal phenotype, suppressible by sauf^P4

(Marcilliere and Limbourg-Bouchon, 1997)

Other

Statement

Reference

Su(fu)^LP, fu^RX2 has lethal phenotype

(Marcilliere and Limbourg-Bouchon, 1997)

Phenotype Manifest In

Enhanced by

Statement

Reference

fu^RX2 has costal vein phenotype, enhanceable by Scer\GAL4^ptc-559.1/Hsap\STK36^UAS.Δ77-98

(Daoud and Blanchet-Tournier, 2005)

fu^RX2 has phenotype, enhanceable by Su(fu)^LP

(Preat et al., 1993)

NOT Enhanced by

Statement

Reference

fu^RX2 has discal cell phenotype, non-enhanceable by Scer\GAL4^ptc-559.1/Hsap\STK36^UAS.Δ77-98

(Daoud and Blanchet-Tournier, 2005)

fu^RX2 has wing vein L3 phenotype, non-enhanceable by Scer\GAL4^ptc-559.1/Hsap\STK36^UAS.Δ77-98

(Daoud and Blanchet-Tournier, 2005)

fu^RX2 has wing vein L4 phenotype, non-enhanceable by Scer\GAL4^ptc-559.1/Hsap\STK36^UAS.Δ77-98

(Daoud and Blanchet-Tournier, 2005)

fu^RX2 has wing basal cell 2 phenotype, non-enhanceable by Scer\GAL4^ptc-559.1/Hsap\STK36^UAS.Δ77-98

(Daoud and Blanchet-Tournier, 2005)

Suppressor of

Statement

Reference

fu^RX2 is a suppressor of wing cell phenotype of Scer\GAL4^71B, smo^ΔFU.UAS

(Malpel et al., 2007)

fu^RX2/fu[+] is a suppressor | partially of wing cell phenotype of Scer\GAL4^71B, smo^ΔFU.UAS

(Malpel et al., 2007)

fu^RX2 is a suppressor of wing cell phenotype of Scer\GAL4^71B, smo^UAS.GFP

(Malpel et al., 2007)

fu^RX2/fu[+] is a suppressor of wing cell phenotype of Scer\GAL4^71B, smo^UAS.GFP

(Malpel et al., 2007)

Other

Statement

Reference

Hsap\STK36^UAS.Δ77-98, Scer\GAL4^ptc-559.1, fu^RX2 has costal vein phenotype

(Daoud and Blanchet-Tournier, 2005)

Su(fu)^LP, fu^RX2 has wing phenotype

(Preat et al., 1993)

Su(fu)^LP, fu^RX2 has leg phenotype

(Preat et al., 1993)

Su(fu)^LP, fu^RX2 has haltere phenotype

(Preat et al., 1993)

Su(fu)^LP, fu^RX2 has wing blade anterior compartment phenotype

(Preat et al., 1993)

Su(fu)^LP, fu^RX2 has leg anterior compartment phenotype

(Preat et al., 1993)

Su(fu)^LP, fu^RX2 has haltere anterior compartment phenotype

(Preat et al., 1993)

Additional Comments

Genetic Interactions

Statement

Reference

Hsap\fu^{Scer\UAS.Δ77-98}; Scer\GAL4^ptc-559.1 does not significantly suppress fusion of wing veins L3 and L4 seen in fu^RX2 hemizygotes, but often leads to a small overgrowth of the costa.

(Daoud and Blanchet-Tournier, 2005)

fu^RX2; Su(fu)^LP/+ flies have a lethal cos-like phenotype. fu^RX2 sauf^P4; Su(fu)^LP/+ flies are viable with a fu phenotype.

(Marcilliere and Limbourg-Bouchon, 1997)

When in combination with Su(fu)^LP or cos³ heterozygotes individuals die as pupae. Adult escapers display wings, halteres and legs that have duplication of structures in the anterior compartment and shortening along the proximal-distal axis. Embryos derived from heterozygotes with Su(fu) mutants display a segment polarity phenotype: thoracic denticle belts are absent, last two rows of abdominal denticle belts are absent and a mirror image duplication of anterior rows of abdominal denticle belts.

(Preat et al., 1993)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Class II mutation based on interaction with Su(fu)^LP, suppression of embryonic and adult phenotype but display an additional phenotype.

(Therond et al., 1996)

Class II allele.

(Robbins et al., 1997)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

fu^RX2

(Ranieri et al., 2014, Malpel et al., 2007)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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