FB2024_03 , released June 25, 2024
Allele: Dmel\HphUAS.cFa
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General Information
Symbol
Dmel\HphUAS.cFa
Species
D. melanogaster
Name
FlyBase ID
FBal0183285
Feature type
allele
Associated gene
Dmel\Hph
Associated Insertion(s)
Carried in Construct
P{UAS-Hph.F}
Also Known As
UAS-Hph
Key Links
Transgenic product class
cDNA
(Frei and Edgar, 2004)
wild_type
(Frei and Edgar, 2004)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Frei and Edgar, 2004)
wild_type
(Frei and Edgar, 2004)
Mutagen
in vitro construct
(Frei et al., 2005, Frei and Edgar, 2004)
Progenitor genotype
Carried in construct
P{UAS-Hph.F}
Cytology
Description

Expression of a XhoI BglII fragment of full length Hph cDNA (GH23732) is under the control of UASt sequences.

(Frei and Edgar, 2004)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hph
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of HphScer\UAS.cFa in border follicle cells under the control of Scer\GAL4slbo.2.6 results in accelerated migration.

      (Doronkin et al., 2010)

      Clonal expression of HphScer\UAS.cFa leads to an overgrowth phenotype.

      (Frei et al., 2005)

      Somatic clones of HphScer\UAS.cFa; Scer\GAL4Act5C.PP in the late third instar wing disc are larger than twinspot control clones.

      (Frei and Edgar, 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      HphUAS.cFa, Scer\GAL4Act5C.PP has abnormal cell growth | somatic clone phenotype, suppressible by mRpL1210534

      (Frei et al., 2005)
      NOT suppressed by
      Statement
      Reference

      HphUAS.cFa, Scer\GAL4Act5C.PP has abnormal size | somatic clone phenotype, non-suppressible by Cdk43

      (Frei and Edgar, 2004)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      When HphScer\UAS.cFa is driven in a Scer\GAL4Act5C.PP background no extra growth is seen.

      (Frei et al., 2005)

      Overgrowth of HphScer\UAS.cFa; Scer\GAL4Act5C.PP somatic clones in third instar wing discs is unaffected by Cdk43/Cdk43.

      (Frei and Edgar, 2004)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      HphUAS.cFa/Scer\GAL4hs.PB rescues HphS030304/Hph02255

      (Frei and Edgar, 2004)
      Comments

      P{UAS-Hph.F}II.1; P{UAS-Hph.F}II.2; Scer\GAL4hs.PB rescues the lethality of Hph02255/HphS030304 even in the absence of heat shock. HphScer\UAS.cFa rescues the increase in ommatidial size in Cdk4Scer\UAS.cMa; CycDScer\UAS.cDa; Scer\GAL4GMR.PF suppressed by Hph02255/+ or HphS030304/+.

      (Frei and Edgar, 2004)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      HphScer\UAS.cFa
      HphUAS.cFa
      Name Synonyms
      Secondary FlyBase IDs
        References (4)