FB2024_03 , released June 25, 2024
Allele: Dmel\Fer3HCHUAS.cMa
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General Information
Symbol
Dmel\Fer3HCHUAS.cMa
Species
D. melanogaster
Name
FlyBase ID
FBal0190585
Feature type
allele
Associated gene
Dmel\Fer3HCH
Associated Insertion(s)
Carried in Construct
P{UAS-Fer3HCH.M}
Also Known As
UAS-Fer3HCH
Key Links
Transgenic product class
wild_type
(Missirlis et al., 2006)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Missirlis et al., 2006)
Mutagen
in vitro construct
(Missirlis et al., 2006)
Progenitor genotype
Carried in construct
P{UAS-Fer3HCH.M}
Cytology
Description

UASt regulatory sequences drive expression of Fer3HCH coding sequences.

(Missirlis et al., 2006)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Fer3HCH
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Friedreich ataxia
      modeled by fh1
      (Chen et al., 2016)
      modeled by fhRNAi.UAS.cLa
      (Navarro et al., 2015)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Adult flies overexpressing Fer3HCHScer\UAS.cMa under the control of Scer\GAL4Act5C exhibit no apparent phenotype under adequate dietary iron. In contrast, female flies that develop and are maintained throughout their lifespan on food containing 0.2mM iron chelator (BPS-bathophenanthroline disulfonic acid) exhibit a 25% decrease in their mean life span. This phenotype is negligible in male flies. Expression of Fer3HCHScer\UAS.cMa (under the control of Scer\GAL4Act5C) confers a robust protection from paraquat toxicity in young adult female flies.

      (Missirlis et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of Fer3HCHScer\UAS.cMa under the control of Scer\GAL4ninaE.PT significantly rescues the neurodegeneration and electrophysiology defect seen in fh1 mutant photoreceptor clones when flies are raised in the dark.

      (Chen et al., 2016)

      Expression of Fer3HCHScer\UAS.cMa partially suppresses the reduction in lifespan seen in flies expressing fhdsRNA.Scer\UAS.cLa under the control of Scer\GAL4Act5C.PU when fed either normal food or food supplemented with iron. The reduced aconitase levels are not restored by Fer3HCHScer\UAS.cMa.

      (Navarro et al., 2015)

      Expression of Fer3HCHScer\UAS.cMa under the control of Scer\GAL4ple.PF significantly rescues the defects in mitochondrial morphology which are seen in the dopaminergic neurons in Pink1B9 adults.

      Co-expression of Fer3HCHScer\UAS.cMa partially suppresses the defects in mitochondria morphology seen in the dopaminergic neurons of animals NDUFA8GD16787 under the control of Scer\GAL4ple.PF.

      (Esposito et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Fer3HCHScer\UAS.cMa
      Fer3HCHUAS.cMa
      Name Synonyms
      Secondary FlyBase IDs
        References (5)