FB2024_03 , released June 25, 2024
Allele: Dmel\eIF4AUAS.cLa
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General Information
Symbol
Dmel\eIF4AUAS.cLa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Li
FlyBase ID
FBal0190840
Feature type
allele
Associated gene
Dmel\eIF4A
Associated Insertion(s)
Carried in Construct
P{UAS-eIF4A.L}
Key Links
Transgenic product class
cDNA
(Li et al., 2005)
wild_type
(Li et al., 2005)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Li et al., 2005)
wild_type
(Li et al., 2005)
Mutagen
in vitro construct
(Li et al., 2005)
Progenitor genotype
Carried in construct
P{UAS-eIF4A.L}
Cytology
Description

UASt regulatory sequences drive expression of the full length, wild-type eIF4A GM14109 cDNA.

(Li et al., 2005)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
eIF4A
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      eIF4AUAS.cLa/Scer\GAL4hs.PB partially rescues eIF4AYE9

      (Li et al., 2005)
      Comments

      The lethality of eIF-4aYE9/Df(2L)E110 animals is only rescued to a limited extent by expression of eIF-4aScer\UAS.cLa under the control of eIF-4aYE9 using heat shock. However, although the percentage of rescue is low (1.4%), it is significant, as no eIF-4aYE9/Df(2L)E110 adults are recovered in the control cross. The ability of eIF-4aYE9 to suppress the haploinsufficiency of dppH46 is neutralised by expression of eIF-4aScer\UAS.cLa under the control of eIF-4aYE9 using heat shock.

      (Li et al., 2005)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      eIF-4aScer\UAS.cLa
      eIF4AScer\UAS.cLa
      eIF4AUAS.cLa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Li
      (Li et al., 2005)
      Secondary FlyBase IDs
        References (1)