FB2024_03 , released June 25, 2024
Allele: Dmel\ThorY54A.M59A.UAS
Open Close
General Information
Symbol
Dmel\ThorY54A.M59A.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0191718
Feature type
allele
Associated gene
Dmel\Thor
Associated Insertion(s)
Carried in Construct
P{UAS-Thor.Y54A.M59A}
Key Links
Transgenic product class
missense_variant
(Tettweiler et al., 2005)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Tettweiler et al., 2005)
Mutagen
in vitro construct
(Tettweiler et al., 2005)
Progenitor genotype
Carried in construct
P{UAS-Thor.Y54A.M59A}
Cytology
Description

UAS regulatory sequences drive expression of a mutated form of Thor (carries the amino acid replacements Y54A and M59A).

(Tettweiler et al., 2005)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Thor
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Larvae expressing ThorY54A.M59A.Scer\UAS under the control of Scer\GAL4hs.PB resist nutritional stress somewhat better in the first 12 hours, but after 36 hours of complete starvation their survival is as poor as in a null allele and is far lower than that of control animals (a survival rate of 8.5% compared to 27.6% in Oregon-R).

      (Tettweiler et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      ThorY54A.M59A.UAS/Scer\GAL4hs.PB fails to rescue ThorΔ1034-2617

      (Tettweiler et al., 2005)
      Comments

      Expression of ThorY54A.M59A.Scer\UAS, under the control of Scer\GAL4hs.PB does not rescue the increased sensitivity of ThorΔ1034-2617 larvae to starvation. Expression of ThorY54A.M59A.Scer\UAS under the control of Scer\GAL4hs.PB does not rescue oxidative stress sensitivity (median life-span of 24.1 hours, 0.4% survival rate at 60 hours).

      (Tettweiler et al., 2005)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      ThorY54A.M59A.Scer\UAS
      ThorY54A.M59A.UAS
      d4E-BP(Y54A, M59A)
      (Tettweiler et al., 2005)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)