FlyBase Allele Report: Dmel\mad2[EY21687]

General Information

Symbol

Dmel\mad2^EY21687

Species

D. melanogaster

Name

FlyBase ID

FBal0192641

Feature type

allele

Associated gene

Dmel\mad2

Associated Insertion(s)

P{EPgy2}mad2^EY21687

Carried in Construct

Also Known As

mad2^EY

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - molecular evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Li et al., 2010)

Mutagen

P-element activity

(Bellen, 2006.8.3)

Progenitor genotype

Associated Insertion(s)

P{EPgy2}mad2^EY21687

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{EPgy2}

misexpression element

Regulatory region(s)

UASp

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:5,812,578..5,812,578 [-]

(Ebrahimi et al., 2010, Li et al., 2010, Bellen, 2006.8.3)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

mad2^EY21687 mutant flies develop normally.

(Li et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

mad2^EY21687, polo^S132408 has abnormal mitotic cell cycle phenotype, suppressible by polo^{D166N.UAS.GFP}/Scer\GAL4^da.G32

(Ebrahimi et al., 2010)

mad2^EY21687, polo^S132408 has decreased cell death phenotype, suppressible by polo^{D166N.UAS.GFP}/Scer\GAL4^da.G32

(Ebrahimi et al., 2010)

Suppressor of

Statement

Reference

mad2^EY21687 is a suppressor of abnormal mitotic cell cycle phenotype of polo^S132408

(Ebrahimi et al., 2010)

mad2^EY21687 is a suppressor of increased cell death phenotype of polo^S132408

(Ebrahimi et al., 2010)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

A mad2^EY21687 background suppresses the mitotic arrest found in polo^S132408 mutants. A mad2^EY21687 background reduces the rate of apoptosis in polo^S132408 mutants close to that of wild-type cells.

Expression of polo^{Scer\UAS.T:Avic\GFP} under the control of Scer\GAL4^da.G32 in a polo^S132408 and mad2^EY21687 double mutants results in the majority of cells undergoing normal cytokinesis and mitosis.

Expression of polo^{D166N.Scer\UAS.T:Avic\GFP} under the control of Scer\GAL4^da.G32 in a polo^S132408 and mad2^EY21687 double mutants results in metaphase arrest.

(Ebrahimi et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

22495

y¹ w^67c23; P{EPgy2}mad2^EY21687/TM3, Sb¹ Ser¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

EY21687

(Li et al., 2007)

mad2^EY21687

(Garrido et al., 2020, Bellen, 2006.8.3)

mad2^EY

(Islam et al., 2023, Garrido et al., 2020, Li et al., 2010)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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