FB2024_03 , released June 25, 2024
Allele: Dmel\SLC5A11EY21708
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General Information
Symbol
Dmel\SLC5A11EY21708
Species
D. melanogaster
Name
FlyBase ID
FBal0192644
Feature type
allele
Associated gene
Dmel\SLC5A11
Associated Insertion(s)
P{EPgy2}SLC5A11EY21708
Carried in Construct
Also Known As
SLC5A111
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Bellen, 2006.8.3)
Progenitor genotype
Associated Insertion(s)
P{EPgy2}SLC5A11EY21708
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{EPgy2}
Regulatory region(s)
UASp
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      SLC5A11EY21708 mutant adults lack the significant increase in activity of ellipsoid body R4 neurons and the significant increase in preference for nutritive sugars seen in starved versus fed flies, compared to controls; these, SLC5A11EY21708/Df(2L)BSC228 and SLC5A11EY21708/Df(2L)BSC229 flies also lack the significant increase in preference for food (vinegar) odor seen in starved versus fed flies, compared to controls.

      (Park et al., 2016)

      Homozygous flies show defects in taste-independent nutrient selection. They fail to show the wild-type preference of D-glucose (nutritive sugar) over L-glucose (non-metabolizable sugar) in a two choice assay when starved. The mutant instead chooses based on the palatability alone: when D-glucose is more concentrated, and presumably sweeter the mutant prefers D-glucose to L-glucose, and conversely, when L-glucose is more concentrated, the flies choose L-glucose over D-glucose. SLC5A11EY21708/SLC5A11UY1824, SLC5A11EY21708/Df(2L)BSC228 and SLC5A11EY21708/Df(2L)BSC229 flies show the same defect in taste-independent nutrient selection.

      Homozygous flies also fail to show the the normal preference for sorbitol, trehalose and galactose which is seen in wild-type flies in a two choice assay when starved.

      (Dus et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhancer of
      Statement
      Reference

      SLC5A11EY21708 is a non-enhancer of abnormal feeding behavior | adult stage | nutrition conditional phenotype of KCNQJF02562, Scer\GAL4SLC5A11.1.1

      (Park et al., 2016)

      SLC5A11EY21708 is a non-enhancer of abnormal feeding behavior | adult stage | nutrition conditional phenotype of KCNQJF02562, Scer\GAL4GMR38H02

      (Park et al., 2016)
      NOT Suppressor of
      Statement
      Reference

      SLC5A11EY21708 is a non-suppressor of abnormal feeding behavior | adult stage | nutrition conditional phenotype of KCNQJF02562, Scer\GAL4SLC5A11.1.1

      (Park et al., 2016)

      SLC5A11EY21708 is a non-suppressor of abnormal feeding behavior | adult stage | nutrition conditional phenotype of KCNQJF02562, Scer\GAL4GMR38H02

      (Park et al., 2016)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      SLC5A11EY21708 Gr64a1 Gr5aunspecified triple mutants show an equal preference for D-glucose and L-glucose in a two-choice assay after 18 hours of starvation.

      (Dus et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Precise excision of the insertion reverts the defect in taste-independent nutrient selection.

      (Dus et al., 2013)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      CG8451EY21708
      (Bellen, 2006.8.3)
      SLC5A111
      (Park et al., 2016, Dus et al., 2013)
      SLC5A11EY21708
      Name Synonyms
      Secondary FlyBase IDs
        References (3)