FB2024_03 , released June 25, 2024
Allele: Dmel\Rab11QL.UAS
Open Close
General Information
Symbol
Dmel\Rab11QL.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0193831
Feature type
allele
Associated gene
Dmel\Rab11
Associated Insertion(s)
Carried in Construct
P{UAS-Rab11.QL}
Also Known As
UAS-Rab11CA
Key Links
Transgenic product class
missense_variant
(Emery et al., 2005)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Emery et al., 2005)
Mutagen
in vitro construct
(Emery et al., 2005)
Progenitor genotype
Carried in construct
P{UAS-Rab11.QL}
Cytology
Description

Amino acid replacement: Q70L.

(Emery et al., 2005)

UASt regulatory sequences drive expression of a mutated form of Rab11.

(Emery et al., 2005)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Rab11
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Scer\GAL4He.PZ-driven expression of Rab11QL.Scer\UAS does not induce increase in the number of circulating hemocytes in third instar larvae relative to controls.

      (Del Signore et al., 2017)

      Expression of Rab11QL.Scer\UAS under the control of Scer\GAL4sca-109-68 at 29oC leads to the production of external sensory organs with multiple sockets and no hair in ~9.5% of cases.

      (Emery et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Suppressor of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The increased number of circulating hemocytes along with the increase in F-actin and the expansion of the LysoTracker-positive compartments in the mutant cells characteristic for OcrlΔ3 mutant third instar larvae is partially suppressed by Scer\GAL4He.PZ-driven expression of Rab11QL.Scer\UAS, but the adult lethality of OcrlΔ3 animals is not rescued.

      (Del Signore et al., 2017)

      Coexpression of Rab11QL.Scer\UAS and nufEP3324, under the control of Scer\GAL4sca-109-68, leads to an enhancement of the hair to socket transformations seen when either transgene is expressed alone.

      (Emery et al., 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Rab11CA
      (Del Signore et al., 2017)
      Rab11QL.Scer\UAS
      Rab11QL.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (4)