FB2024_03 , released June 25, 2024
Allele: Dmel\Su(fu)UAS.cDa
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General Information
Symbol
Dmel\Su(fu)UAS.cDa
Species
D. melanogaster
Name
FlyBase ID
FBal0193956
Feature type
allele
Associated gene
Dmel\Su(fu)
Associated Insertion(s)
Carried in Construct
P{UAS-Su(fu).D}
Key Links
Transgenic product class
wild_type
(Dussillol-Godar et al., 2006)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Dussillol-Godar et al., 2006)
Mutagen
in vitro construct
(Dussillol-Godar et al., 2006)
Progenitor genotype
Carried in construct
P{UAS-Su(fu).D}
Cytology
Description

UASt regulatory sequences drive expression of full-length Su(fu).

(Dussillol-Godar et al., 2006)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Su(fu)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Escaper adult flies expressing Su(fu)Scer\UAS.cDa under the control of Scer\GAL4da.G32 show anterior duplications in the wing, legs and antennae. In the wing, the domain between the costa and subcosta is enlarged with frequent expanded costa duplications and there are extra, disorganized costa bristles. However, these wings do not show obvious anomalies in the LV3-LV4 region. The first pair of legs belonging to these escapers are shorter and thicker than in wild type and have anterior sex-comb duplications. Legs of the third pair are extremely deformed, with enlarged and fused articles.

      Adult flies that express Su(fu)Scer\UAS.cDa under the control of Scer\GAL4vg.int2.1 have frequent anomalies in the costa region of the wing, leading to large anterior duplications.

      Anterior clones expressing Su(fu)Scer\UAS.cDa under the control of Scer\GAL4Act5C.PP in the wing disc lead to disc overgrowth.

      (Dussillol-Godar et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Phenotype Manifest In
      Enhanced by
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      In escaper flies that express Su(fu)Scer\UAS.cDa, under the control of Scer\GAL4da.G32, in a fu41 background, the wing phenotype is enhanced compared to flies expressing the transgene in a wild-type background. fu41, Su(fu)Scer\UAS.cDa, Scer\GAL4da.G32 wings show anterior duplications but also have a truncated vein 2, an enlargement of the domain between vein 2 and the margin, and veins 3 and 4 are completely fused with a large delta at the margin. These flies also show an enhancement of the leg phenotype seen in Su(fu)Scer\UAS.cDa, Scer\GAL4da.G32 flies. Flies expressing Su(fu)Scer\UAS.cDa under the control of Scer\GAL4da.G32 in a fu1 background show the same phenotypes as those with a fu41 background.

      (Dussillol-Godar et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Su(fu)Scer\UAS.cDa
      Su(fu)UAS.cDa
      Name Synonyms
      Secondary FlyBase IDs
        References (2)