FB2024_03 , released June 25, 2024
Allele: Dmel\XNPRNAi.UAS.WIZ
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General Information
Symbol
Dmel\XNPRNAi.UAS.WIZ
Species
D. melanogaster
Name
FlyBase ID
FBal0195554
Feature type
allele
Associated gene
Dmel\XNP
Associated Insertion(s)
Carried in Construct
P{UAS-XNP.RNAi.WIZ}
Key Links
Transgenic product class
RNAi_reagent
(Sun et al., 2006)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Sun et al., 2006)
Mutagen
in vitro construct
(Sun et al., 2006)
Progenitor genotype
Carried in construct
P{UAS-XNP.RNAi.WIZ}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat of a 697bp XNP fragment (corresponding to nucleotides 3181--3837 of the LD28477 cDNA).

(Sun et al., 2006)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
XNP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Fas2-positive longitudinal axons aberrantly cross the central nervous system midline and there are breaks in the longitudinal connectives in stage 16 embryos expressing XNPdsRNA.Scer\UAS.WIZ under the control of Scer\GAL4elav.PLu.

      robo-positive axons cross the central nervous system midline in stage 16 embryos expressing XNPdsRNA.Scer\UAS.WIZ under the control of Scer\GAL4elav.PLu.

      Longitudinal glia inappropriately occupy positions at the central nervous system midline in stage 12 embryos expressing XNPdsRNA.Scer\UAS.WIZ under the control of Scer\GAL4gcm.PP.

      robo-positive glia are misplaced medially in stage 12/13 embryos expressing XNPdsRNA.Scer\UAS.WIZ under the control of Scer\GAL4gcm.PP.

      Embryos expressing XNPdsRNA.Scer\UAS.WIZ under the control of Scer\GAL4elav.PLu have a normal number of glia in the ventral nerve cord at both stage 12 and stage 15. Embryos expressing XNPdsRNA.Scer\UAS.WIZ under the control of Scer\GAL4gcm.PP have a normal number of glia in the ventral nerve cord at stage 12, but the number of glia is reduced compared to controls at stage 15.

      (Sun et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Longitudinal fascicles fuse into a single tract at the midline in stage 16 embryos co-expressing jingdsRNA.Scer\UAS.WIZ and XNPdsRNA.Scer\UAS.WIZ under the control of Scer\GAL4elav.PLu.

      (Sun et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      XNPRNAi.UAS.WIZ
      XNPdsRNA.Scer\UAS.WIZ
      XNPdsRNA.UAS.WIZ
      Name Synonyms
      Secondary FlyBase IDs
        References (2)