FB2024_03 , released June 25, 2024
Allele: Scer\GAL4gcm-rA87.P
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General Information
Symbol
Scer\GAL4gcm-rA87.P
Species
S. cerevisiae
Name
FlyBase ID
FBal0244818
Feature type
allele
Associated gene
Scer\GAL4
Associated Insertion(s)
P{GawB}gcmrA87.P
Carried in Construct
Also Known As
gcm-GAL4, gcmGal4
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
gene conversion
(Paladi and Tepass, 2004)
P-element activity
(Paladi and Tepass, 2004)
Progenitor genotype
P{PZ}gcmrA87
(Paladi and Tepass, 2004)
Associated Insertion(s)
P{GawB}gcmrA87.P
Cytology
Description

The P{PZ} element of the P{PZ}gcmrA87 insertion has been replaced with a P{GawB} element.

(Paladi and Tepass, 2004)
Allele components
Component
Use(s)
Inserted element
P{GawB}
Encoded product / tool
GAL4
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      distribution deduced from reporter (Gal4 UAS)
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      embryonic stage 1 -- 11
      hemocyte
      (Cho et al., 2002)
      embryonic stage 8
      head mesoderm
      (Trébuchet et al., 2019)
      embryonic stage 11 -- 17
      hemocyte
      (Sears et al., 2003)
      embryonic stage 14
      glial cell | subset
      (Freeman et al., 2003)
      first instar larval stage -- third instar larval stage
      larval prothoracic A-subperineurial glial cell
      (Soustelle and Giangrande, 2007)
      larval mesothoracic A-subperineurial glial cell
      (Soustelle and Giangrande, 2007)
      larval metathoracic A-subperineurial glial cell
      (Soustelle and Giangrande, 2007)
      third instar larval stage
      adult medulla neuropil associated glial cell
      (Soustelle and Giangrande, 2007)
      embryonic/larval brain | restricted
      (Soustelle and Giangrande, 2007)
      larval ventral midline glial cell
      (Soustelle and Giangrande, 2007)
      larval ventral nerve cord | restricted

      Comment: four pairs of neurons within the dorsal region

      (Soustelle and Giangrande, 2007)
      pupal stage
      presumptive spermatheca
      (Cattenoz et al., 2016)
      adult stage | female
      spermatheca
      (Cattenoz et al., 2016)
      Additional Information
      Statement
      Reference

      gcm reporter is expressed early in the development of the secretory cells of the spermathecum during pupal stages. In adults, reporter is detected in the spermathecum but not in the ovaries or oviduct.

      (Cattenoz et al., 2016)

      In addition to expression in glial precursor cells and lamina precursor cells in the third instar larval optic lobe and a central brain cluster, reporter expression is observed in medulla neuropil glial cells. Reporter expression is also observed in in the ventral nerve cord in leg neuropile glia and in four pairs of neurons within the dorsal region of the ventral nerve cord.

      (Soustelle and Giangrande, 2007)

      Embryonic expression is observed in all non-midline glial cells.

      (Freeman et al., 2003)
       
      Marker for
      glial cell
      (Freeman et al., 2003)
      hemocyte
      (Sears et al., 2003, Cho et al., 2002)
      Reflects expression of
      gcm
      (Cattenoz et al., 2016, Soustelle and Giangrande, 2007, Freeman et al., 2003, Sears et al., 2003, Cho et al., 2002)
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      NOT Enhancer of
      Statement
      Reference

      gcmJF01075/Scer\GAL4gcm-rA87.P is a non-enhancer of lamellocyte | larval stage | increased number phenotype of Tl10b

      (Bazzi et al., 2023)
      NOT Suppressor of
      Statement
      Reference

      gcmJF01075/Scer\GAL4gcm-rA87.P is a non-suppressor of lamellocyte | increased number | larval stage phenotype of Tl10b

      (Bazzi et al., 2023)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Scer\GAL4gcm-rA87.P
      Scer\GAL4gcm.PP
      Scer\GAL4gcm.cPa
      Name Synonyms
      Secondary FlyBase IDs
      • FBal0141431
      • FBal0244166
      References (17)