FlyBase Allele Report: Dmel\Ephrin[UAS.Tag:MYC]

General Information

Symbol

Dmel\Ephrin^UAS.Tag:MYC

Species

D. melanogaster

Name

FlyBase ID

FBal0196834

Feature type

allele

Associated gene

Dmel\Ephrin

Associated Insertion(s)

Carried in Construct

P{UAS-Ephrin.MYC}

Also Known As

Ephrin-myc

Key Links

Transgenic product class

cDNA

(Boyle et al., 2006)

wild_type

(Boyle et al., 2006)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Boyle et al., 2006)

wild_type

(Boyle et al., 2006)

Mutagen

in vitro construct

(Boyle et al., 2006)

Progenitor genotype

Carried in construct

P{UAS-Ephrin.MYC}

Cytology

Description

UAS regulatory sequences drive expression of Ephrin, which is tagged in-frame to 6 copies of the Tag:MYC epitope. The Ephrin sequence corresponds to the full-length cDNA clone RE46807.

(Boyle et al., 2006)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Ephrin

Tagged with

Tag:MYC

epitope tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy, with Scer\GAL4^ey-OK107

(Boyle et al., 2006)

abnormal neuroanatomy, with Scer\GAL4^sim.PS

(Boyle et al., 2006)

Phenotype Manifest In

medial lobe of adult mushroom body, with Scer\GAL4^ey-OK107

(Boyle et al., 2006)

presumptive embryonic/larval central nervous system, with Scer\GAL4^sim.PS

(Boyle et al., 2006)

symmetrical commissure, with Scer\GAL4^sim.PS

(Boyle et al., 2006)

vertical lobe of adult mushroom body, with Scer\GAL4^ey-OK107

(Boyle et al., 2006)

Detailed Description

Statement

Reference

Expression of Ephrin^{Scer\UAS.T:Hsap\MYC} in the midline glia of embryos, driven by Scer\GAL4^sim.PS, leads to the failure of many commissural axons to cross the midline and form normal commissures. The CNS in these embryos often appears less compact.

In the mushroom bodies of adult flies that express Ephrin^{Scer\UAS.T:Hsap\MYC}, under the control of Scer\GAL4^OK107, the dorsal lobes are absent and the medial β projections are thicker. In 50% of cases the β lobes appear to be fused at the midline.

(Boyle et al., 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL4^GH146/Ephrin^UAS.Tag:MYC is a suppressor | partially of abnormal neuroanatomy | somatic clone | adult stage phenotype of meigo¹

(Sekine et al., 2013)

NOT Suppressor of

Statement

Reference

Scer\GAL4^ey-OK107/Ephrin^UAS.Tag:MYC is a non-suppressor of abnormal neuroanatomy phenotype of Eph^x652

(Boyle et al., 2006)

Scer\GAL4^elav.PLu/Ephrin^UAS.Tag:MYC is a non-suppressor of abnormal neuroanatomy phenotype of Eph^x652

(Boyle et al., 2006)

Phenotype Manifest In

Suppressed by

Statement

Reference

Ephrin^UAS.Tag:MYC, Scer\GAL4^sim.PS has symmetrical commissure phenotype, suppressible by Eph^x652

(Boyle et al., 2006)

NOT suppressed by

Statement

Reference

Ephrin^UAS.Tag:MYC, Scer\GAL4^elav.PLu has mushroom body vertical lobe phenotype, non-suppressible by Eph^x652

(Boyle et al., 2006)

Ephrin^UAS.Tag:MYC, Scer\GAL4^ey-OK107 has mushroom body vertical lobe phenotype, non-suppressible by Eph^x652

(Boyle et al., 2006)

Suppressor of

Statement

Reference

Scer\GAL4^GH146/Ephrin^UAS.Tag:MYC is a suppressor | partially of adult antennal lobe projection neuron | somatic clone phenotype of meigo¹

(Sekine et al., 2013)

NOT Suppressor of

Statement

Reference

Scer\GAL4^ey-OK107/Ephrin^UAS.Tag:MYC is a non-suppressor of mushroom body vertical lobe phenotype of Eph^x652

(Boyle et al., 2006)

Scer\GAL4^elav.PLu/Ephrin^UAS.Tag:MYC is a non-suppressor of mushroom body vertical lobe phenotype of Eph^x652

(Boyle et al., 2006)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of Ephrin^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^GH146 partially suppresses the targeting defects seen in homozygous meigo¹ DL1 projection neuron clones.

(Sekine et al., 2013)

Expression of Ephrin^{Scer\UAS.T:Hsap\MYC} in the midline glia of embryos, driven by Scer\GAL4^sim.PS, in an Eph^x652 background does not cause the disruption of commissural axons seen when the transgene is expressed in wild-type embryos.

Flies that express Ephrin^{Scer\UAS.T:Hsap\MYC} under the control of either Scer\GAL4^OK107 or Scer\GAL4^elav.PLu, in an Eph^x652 background, show the same α'/α lobe defects as flies expressing the transgene in a wild-type background and as Eph^x652 flies with no transgene.

(Boyle et al., 2006)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Ephrin^{Scer\UAS.T:Hsap\MYC}

Ephrin^UAS.Tag:MYC

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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