FlyBase Allele Report: Dmel\InR[act.UAS]

General Information

Symbol

Dmel\InR^act.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0198008

Feature type

allele

Associated gene

Dmel\InR

Associated Insertion(s)

Carried in Construct

P{UAS-InR.act}

Also Known As

UAS-dINR^act

Key Links

Transgenic product class

inframe_deletion

(Wittwer et al., 2005)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

inframe_deletion

(Wittwer et al., 2005)

Mutagen

in vitro construct

(Wittwer et al., 2005)

Progenitor genotype

Carried in construct

P{UAS-InR.act}

Cytology

Description

Expression of a mutant form of InR lacking amino acids 309 to 1110 is under the control of UASt sequences.

(Wittwer et al., 2005)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

InR

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

hyperplasia, with Scer\GAL4^GMR.PF

(Wittwer et al., 2005)

Phenotype Manifest In

amnioserosa, with Scer\GAL4^{Orct2-cald-GAL4}

(Mohseni et al., 2009)

eye, with Scer\GAL4^GMR.PF

(Wittwer et al., 2005)

Detailed Description

Statement

Reference

Scer\GAL4^{Orct2-cald-GAL4}-mediated expression of InR^act.Scer\UAS results in downregulation of autophagy and a strong persistent amnioserosa phenotype.

Scer\GAL4^da.G32-mediated expression of InR^act.Scer\UAS does not globally inhibit caspase-dependent programmed cell death.

(Mohseni et al., 2009)

The eyes of InR^act.Scer\UAS; Scer\GAL4^GMR.PF flies have massive overgrowth.

(Wittwer et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

InR^act.UAS, Scer\GAL4^GMR.PF has hyperplasia phenotype, suppressible by B4^UAS.cSa

(Wittwer et al., 2005)

NOT suppressed by

Statement

Reference

InR^act.UAS, Scer\GAL4^GMR.PF has hyperplasia phenotype, non-suppressible by Df(3L)AC1/+

(Wittwer et al., 2005)

Phenotype Manifest In

Suppressed by

Statement

Reference

InR^act.UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible by B4^UAS.cSa

(Wittwer et al., 2005)

NOT suppressed by

Statement

Reference

InR^act.UAS, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Df(3L)AC1/+

(Wittwer et al., 2005)

NOT Suppressor of

Statement

Reference

InR^act.UAS, Scer\GAL4^Myo31DF.PU is a non-suppressor of hemolymph phenotype of ImpL2^UAS.cHa, Scer\GAL4^Myo31DF.PU, Scer\GAL80^ts.αTub84B

(Kwon et al., 2015)

InR^act.UAS, Scer\GAL4^Myo31DF.PU is a non-suppressor of ovary phenotype of ImpL2^UAS.cHa, Scer\GAL4^Myo31DF.PU, Scer\GAL80^ts.αTub84B

(Kwon et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of InR^act.Scer\UAS does not suppress the increases in circulating and whole-body trehalose levels and hemolymph volume and ovary atrophy seen when ImpL2^Scer\UAS.cHa is expressed in adult enterocytes (under the control of Scer\GAL4^Myo31DF.PU and limited to the adult stage using Scer\GAL80^ts.αTub84B).

(Kwon et al., 2015)

B4^Scer\UAS.cSa suppresses overgrowth in the eye due to Scer\GAL4^GMR.PF ; InR^act.Scer\UAS. This phenotype is not suppressed by Df(3L)AC1/+.

(Wittwer et al., 2005)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

InR^act.Scer\UAS

InR^act.UAS

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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