UASt regulatory sequences drive expression of an inverted repeat.
Adults expressing S6kGD6646 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.
Expression under the control of Scer\GAL4pnr-MD237 results in bristle morphology defects on the notum in 70-80% of the Scer\GAL4pnr-MD237 expression domain.
S6kGD6646, Scer\GAL4elav.PLu is a suppressor of abnormal neuroanatomy phenotype of RhebUAS.cPa, Scer\GAL4elav.PLu
S6kGD6646, Scer\GAL4FRT.Rnor\Cd2.Act5C is a suppressor of neoplasia phenotype of Ras85DV12.UAS, Scer\GAL4FRT.Rnor\Cd2.Act5C, dlg1GD4689
S6kGD6646, Scer\GAL4repo.PU is a suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Pi3K92EUAS.Tag:MYC,Tag:PM(hKRAS), Scer\GAL4repo.PU, btl::Egfrλ.UAS
S6kGD6646, Scer\GAL4repo.PU is a suppressor of neoplasia | third instar larval stage phenotype of Pi3K92EUAS.Tag:MYC,Tag:PM(hKRAS), Scer\GAL4repo.PU, btl::Egfrλ.UAS
S6kGD6646, Scer\GAL4elav.PLu is a suppressor of photoreceptor cell R7 phenotype of RhebUAS.cPa, Scer\GAL4elav.PLu
S6kGD6646, Scer\GAL4elav.PLu is a suppressor of photoreceptor cell R8 phenotype of RhebUAS.cPa, Scer\GAL4elav.PLu
S6kGD6646, Scer\GAL4repo.PU is a suppressor of glial cell | increased number | third instar larval stage phenotype of Pi3K92EUAS.Tag:MYC,Tag:PM(hKRAS), Scer\GAL4repo.PU, btl::Egfrλ.UAS
S6kGD6646, Scer\GAL4repo.PU is a suppressor of embryonic/larval brain | third instar larval stage phenotype of Pi3K92EUAS.Tag:MYC,Tag:PM(hKRAS), Scer\GAL4repo.PU, btl::Egfrλ.UAS
S6kGD6646, Scer\GAL4elav.PLu is a non-suppressor of embryonic/larval neuromuscular junction phenotype of RhebUAS.cPa, Scer\GAL4elav.PLu
Co-expression of S6kGD6646 significantly rescues the axon guidance phenotypes of RhebScer\UAS.cPa, Scer\GAL4elav.PLu flies.
Co-expression of S6kGD6646 does not rescue the RhebScer\UAS.cPa, Scer\GAL4elav.PLu synapse overgrowth phenotype.
Depletion of S6k, through expression of S6kGD6646, slightly reduces tumour size in Ras85DV12.Scer\UAS-dlg1GD4689 MARCM clones.
Expression of S6kGD6646 significantly suppresses the glial neoplasia seen in third instar larvae when btl::EgfrScer\UAS.T:λ\cI-DD and Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX are co-expressed under the control of Scer\GAL4repo.PU.