UASt regulatory sequences drive expression of an inverted repeat.
lethal | male, with Scer\GAL4Bx-MS1096
Third instar larvae with expression of eIF-4EGD1432 driven by Scer\GAL4elav-C155 do not show significant changes in evoked excitatory postsynaptic potential (EPSP) amplitudes or miniature EPSP (mEPSP) frequency or amplitude (recordings from muscle 6/7 NMJs) compared to controls.
Leaky expression of eIF-4EGD1432 (in the absence of a GAL4) significantly increases the number of extra satellite boutons seen at the neuromuscular junction in third instar larvae.
Expression under the control of Scer\GAL41407 results in loss of neuroblasts in the larval brain associated with decreased size of the remaining neuroblasts.
Expression under the control of Scer\GAL41407 results in a reduction in the average size of neuroblasts together with shorter neuroblast lineages (less daughter cells per neuroblast) in the larval brain compared to controls.
Expression under the control of Scer\GAL41407 results in a decrease in the average size of ganglion mother cells in the larval brain compared to controls.
Adults expressing eIF-4EGD1432 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.
Expression under the control of Scer\GAL4Mef2.PR results in early larval lethality.
Expression under the control of Scer\GAL4Mef2.PR results in split larval body wall muscles.
Expression under the control of Scer\GAL4Mef2.PR results in wild-type sarcomeres in the larval body wall muscles.
Expression of eIF-4EGD1432 under the control of Scer\GAL4Bx-MS1096, results in crinkled and necrotic wings.
eIF4E1GD1432 has abnormal neuroanatomy | third instar larval stage phenotype, enhanceable by cupΔ212/cup[+]
eIF4E1GD1432 has abnormal neuroanatomy | third instar larval stage phenotype, enhanceable by cup[+]/cup20
Scer\GAL4Bx-MS1096, eIF4E1GD1432 has lethal | female phenotype, enhanceable by Dcr-2UAS.cDa, Scer\GAL4Bx-MS1096
eIF4E1GD1432, Scer\GAL4repo.PU is a suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Pi3K92EUAS.Tag:MYC,Tag:PM(hKRAS), Scer\GAL4repo.PU, btl::Egfrλ.UAS
eIF4E1GD1432, Scer\GAL4repo.PU is a suppressor of neoplasia | third instar larval stage phenotype of Pi3K92EUAS.Tag:MYC,Tag:PM(hKRAS), Scer\GAL4repo.PU, btl::Egfrλ.UAS
eIF4E1GD1432 has NMJ bouton | third instar larval stage | increased number phenotype, enhanceable by cupΔ212/cup[+]
eIF4E1GD1432 has NMJ bouton | third instar larval stage | increased number phenotype, enhanceable by cup[+]/cup20
eIF4E1GD1432, Scer\GAL4repo.PU is a suppressor of glial cell | increased number | third instar larval stage phenotype of Pi3K92EUAS.Tag:MYC,Tag:PM(hKRAS), Scer\GAL4repo.PU, btl::Egfrλ.UAS
eIF4E1GD1432, Scer\GAL4repo.PU is a suppressor of embryonic/larval brain | third instar larval stage phenotype of Pi3K92EUAS.Tag:MYC,Tag:PM(hKRAS), Scer\GAL4repo.PU, btl::Egfrλ.UAS
cupΔ212/+ or cup20/+ significantly enhances the number of extra satellite boutons seen at the neuromuscular junction in third instar larvae with eIF-4EGD1432 (in the absence of a GAL4).
Expression of eIF-4EGD1432 significantly suppresses the glial neoplasia seen in third instar larvae when btl::EgfrScer\UAS.T:λ\cI-DD and Pi3K92EScer\UAS.T:Hsap\MYC,T:Hsap\CAAX are co-expressed under the control of Scer\GAL4repo.PU.