FB2024_03 , released June 25, 2024
Allele: Dmel\rictorUAS.cHa
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General Information
Symbol
Dmel\rictorUAS.cHa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Hietkangas
FlyBase ID
FBal0215850
Feature type
allele
Associated gene
Dmel\rictor
Associated Insertion(s)
Carried in Construct
P{UAS-rictor.H}
Also Known As
UAS-rictor
Key Links
Transgenic product class
wild_type
(Hietakangas and Cohen, 2007)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Hietakangas and Cohen, 2007)
Mutagen
in vitro construct
(Hietakangas and Cohen, 2007)
Progenitor genotype
Carried in construct
P{UAS-rictor.H}
Cytology
Description

UASt regulatory sequences drive expression of the rictor coding region.

(Hietakangas and Cohen, 2007)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
rictor
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      DOES NOT ameliorate  Parkinson's disease
      modeled by park1, parkΔ21
      (Wu et al., 2013)
      ameliorates  Parkinson's disease
      modeled by Pink1RNAi.UAS.cYa
      (Wu et al., 2013)
      modeled by Pink1B9
      (Wu et al., 2013)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of rictorScer\UAS.cHa under the control of Scer\GAL4tub in an otherwise wild-type background does not affect the total body weight or wing area of flies raised under controlled conditions on a rich diet.

      (Hietakangas and Cohen, 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      NOT Enhancer of
      Statement
      Reference

      rictorUAS.cHa/Scer\GAL4da.PU is a non-enhancer of visible phenotype of parkΔ21/park1

      (Wu et al., 2013)
      Suppressor of
      NOT Suppressor of
      Statement
      Reference

      rictorUAS.cHa/Scer\GAL4da.PU is a non-suppressor of visible phenotype of parkΔ21/park1

      (Wu et al., 2013)
      Phenotype Manifest In
      Enhancer of
      NOT Enhancer of
      Statement
      Reference

      rictorUAS.cHa/Scer\GAL4da.PU is a non-enhancer of wing phenotype of parkΔ21/park1

      (Wu et al., 2013)

      rictorUAS.cHa/Scer\GAL4da.PU is a non-enhancer of mitochondrion phenotype of parkΔ21/park1

      (Wu et al., 2013)
      Suppressor of
      NOT Suppressor of
      Statement
      Reference

      rictorUAS.cHa/Scer\GAL4da.PU is a non-suppressor of wing phenotype of parkΔ21/park1

      (Wu et al., 2013)

      rictorUAS.cHa/Scer\GAL4da.PU is a non-suppressor of mitochondrion phenotype of parkΔ21/park1

      (Wu et al., 2013)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of rictorScer\UAS.cHa enhances the increase in the number of type II neuroblasts which is seen in the central brain of animals expressing NScer\UAS.T:SV5\V5,T:Zzzz\His6 under the control of Scer\GAL4pnt-14-94.

      (Lee et al., 2013)

      The mitochondrial aggregation phenotype seen in the muscles of flies expressing Pink1dsRNA.Scer\UAS under the control of Scer\GAL4Mhc.PW is strongly suppressed by co-expression of rictorScer\UAS.cHa.

      The mitochondrial aggregation phenotype seen in the dopaminergic neurons of Pink1B9 flies is strongly suppressed by expression of rictorScer\UAS.cHa under the control of Scer\GAL4ple.PF.

      The loss of dopaminergic neurons in the PPL1 cluster seen in Pink1B9 flies is suppressed by expression of rictorScer\UAS.cHa under the control of Scer\GAL4ple.PF.

      Expression of rictorScer\UAS.cHa under the control of Scer\GAL4da.PU fails to rescue the abnormal wing posture and mitochondrial aggregation phenotypes seen in park1/parkΔ21 flies.

      (Wu et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      rictorUAS.cHa/Scer\GAL4unspecified rescues rictorΔ2

      (Koike-Kumagai et al., 2009)

      rictorUAS.cHa/Scer\GAL4ppk.PG rescues rictorΔ2

      (Koike-Kumagai et al., 2009)

      rictorUAS.cHa/Scer\GAL4Tub.PU rescues rictorΔ2

      (Hietakangas and Cohen, 2007)
      Comments

      Class IV neuron-specific expression of rictorScer\UAS.cHa largely rescues the dendritic phenotypes of single-cell rictorΔ2 class IV dendrite arborization neuron clones.

      Expression of rictorScer\UAS.cHa under the control of Scer\GAL4ppk.PG largely rescues the tiling defects seen in v'ada and vdaB neurons of rictorΔ2 mutants.

      (Koike-Kumagai et al., 2009)

      The reduced body weight and wing area seen in rictorΔ2 flies raised under controlled conditions on a rich diet are rescued by expression of rictorScer\UAS.cHa under the control of Scer\GAL4tub.

      (Hietakangas and Cohen, 2007)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      rictorScer\UAS.cHa
      rictorUAS.cHa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Hietkangas
      Secondary FlyBase IDs
        References (4)