FB2024_03 , released June 25, 2024
Allele: Dmel\MadSDVD.UAS
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General Information
Symbol
Dmel\MadSDVD.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0217507
Feature type
allele
Associated gene
Dmel\Mad
Associated Insertion(s)
Carried in Construct
P{UAS-Mad.SDVD}
Also Known As
MAD-SDVD
Key Links
Transgenic product class
missense_variant
(Gesualdi and Haerry, 2007)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Gesualdi and Haerry, 2007)
Mutagen
in vitro construct
(Gesualdi and Haerry, 2007)
Progenitor genotype
Carried in construct
P{UAS-Mad.SDVD}
Cytology
Description

Amino acid replacement: S?D.

(Gesualdi and Haerry, 2007)

UAS regulatory sequences drive expression of Mad coding sequence in which the last two serine residues within the C-terminal SSXS motive with two aspartic acids.

(Gesualdi and Haerry, 2007)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Mad
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of MadSDVD.UAS under the control of Scer\GAL4Mef2.PR does not have an obvious effect on the amplitude of excitatory junctional currents (eEJCs) at the larval neuromuscular junction, as compared to controls.

      (Augustin et al., 2017)

      Expression of MadSDVD.Scer\UAS under the control of Scer\GAL4A9 results in mild wing vein patterning defects.

      (Haerry, 2010)

      Expression of one copy of MadSDVD.Scer\UAS in the wing, under the control of Scer\GAL4A9, results in wings of almost normal size that exhibit some ectopic vein tissue. Expression of two copies of MadSDVD.Scer\UAS results in slightly enhanced growth and more severe vein defects. Expression of four copies of MadSDVD.Scer\UAS is sufficient to transform many cells into vein tissue.

      (Gesualdi and Haerry, 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      MadSDVD.UAS, Scer\GAL4A9 has visible phenotype, enhanceable by putUAS.cNa, Scer\GAL4A9

      (Haerry, 2010)
      NOT Enhancer of
      Statement
      Reference

      MadSDVD.UAS, Scer\GAL4A9 is a non-enhancer of visible phenotype of Scer\GAL4A9, saxQ263D.UAS.Tag:HA

      (Haerry, 2010)
      NOT Suppressor of
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      MadSDVD.UAS, Scer\GAL4A9 has wing vein phenotype, enhanceable by putUAS.cNa, Scer\GAL4A9

      (Haerry, 2010)
      NOT Enhancer of
      Statement
      Reference

      MadSDVD.UAS, Scer\GAL4A9 is a non-enhancer of wing vein phenotype of Scer\GAL4A9, saxQ263D.UAS.Tag:HA

      (Haerry, 2010)
      NOT Suppressor of
      Statement
      Reference

      MadSDVD.UAS, Scer\GAL4Mef2.PR is a non-suppressor of larva phenotype of Scer\GAL4Mef2.PR, myoRNAi.UAS

      (Augustin et al., 2017)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of MadSDVD.Scer\UAS in animals expressing saxQ263D.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4A9 does not enhance the wing vein patterning defects.

      Expression of putScer\UAS.cNa in animals expressing MadSDVD.Scer\UAS under the control of Scer\GAL4A9 decreases wing size, and severely disrupts vein patterning.

      (Haerry, 2010)

      Co-expression of two copies of MadSDVD.Scer\UAS and SmoxSDVD.Scer\UAS, all under the control of Scer\GAL4A9, result in a synergistic effect, in the transformation of intervein into vein tissue is observed.

      (Gesualdi and Haerry, 2007)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      MadSDVD.Scer\UAS
      MadSDVD.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (4)