FB2024_03 , released June 25, 2024
Allele: Dmel\Lis-1UAS.Emerald
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General Information
Symbol
Dmel\Lis-1UAS.Emerald
Species
D. melanogaster
Name
FlyBase ID
FBal0217580
Feature type
allele
Associated gene
Dmel\Lis-1
Associated Insertion(s)
Carried in Construct
P{UAS-Lis1.3xEmerald}
Key Links
Transgenic product class
wild_type
(Siller et al., 2005)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Siller et al., 2005)
Mutagen
in vitro construct
(Siller et al., 2005)
Progenitor genotype
Carried in construct
P{UAS-Lis1.3xEmerald}
Cytology
Description

UASt regulatory sequences drive expression of the complete Lis-1 coding sequence which is tagged at the N-terminal end with three copies of the Emerald fluorescent protein.

(Siller et al., 2005)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Lis-1
Tagged with
Emerald
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of Lis-1Scer\UAS.T:Avic\GFP-EMD under the control of Scer\GAL4shot-OK307 does not lead to any giant fiber anatomical or electrophysiological defects, as compared to controls.

      (Kudumala et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Lis-1UAS.Emerald/Scer\GAL4shot-OK307 rescues Lis-1HMS01457

      (Kudumala et al., 2017)
      Comments

      The co-expression of Lis-1Scer\UAS.T:Avic\GFP-EMD rescues the giant fiber anatomical and electrophysiological defects induced by the expression of Lis-1HMS01457 under the control of Scer\GAL4shot-OK307.

      (Kudumala et al., 2017)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Lis-1Scer\UAS.T:Avic\GFP-EMD
      Lis-1UAS.EmGFP
      Lis-1UAS.Emerald
      Name Synonyms
      Secondary FlyBase IDs
        References (2)