FB2024_03 , released June 25, 2024
Allele: Dmel\Cap-H2EY09979
Open Close
General Information
Symbol
Dmel\Cap-H2EY09979
Species
D. melanogaster
Name
FlyBase ID
FBal0219646
Feature type
allele
Associated gene
Dmel\Cap-H2
Associated Insertion(s)
P{EPgy2}Cap-H2EY09979
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{EPgy2}Cap-H2EY09979
    Cytology
    Description

    Insertion 301bp upstream of the 5' end of Cap-H2.

    (Hartl et al., 2008)
    Allele components
    Component
    Use(s)
    Inserted element
    P{EPgy2}
    Regulatory region(s)
    UASp
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In

        embryonic/larval salivary gland | third instar larval stage, with Scer\GAL4hs.PU

        (Buster et al., 2013)

        nuclear envelope, with Scer\GAL4hs.PU

        (Buster et al., 2013)

        polytene chromosome, with Scer\GAL4hs.PU

        (Buster et al., 2013)

        polytene chromosome & larval salivary gland, with Scer\GAL443B

        (Hartl et al., 2008)

        polytene chromosome & larval salivary gland, with Scer\GAL4hs.PB

        (Hartl et al., 2008)

        polytene chromosome & larval salivary gland | conditional - heat sensitive, with Scer\GAL4hs.PB

        (Hartl et al., 2008)
        Detailed Description
        Statement
        Reference

        Expression of Cap-H2EY09979 under the control of Scer\GAL4hs.PU results in unpaired salivary gland chromosomes in third instar larvae. The salivary gland cells have wrinkled nuclear envelopes and 32% have intranuclear microspheres.

        (Buster et al., 2013)

        Expression of Cap-H2EY09979 under the control of Scer\GAL443B results in polytene chromosome disassembly in the salivary gland nuclei of larvae.

        Expression of Cap-H2EY09979 under the control of Scer\GAL4hs.PB in third instar larvae using a heat shock of 24 hours at 35[o]C results in polytene chromosome disassembly, with the extent of dispersal being directly related to the time after Cap-H2 induction that the salivary glands are examined. Significant disassembly of the polytene chromosomes is seen after 6 hours of Cap-H2 induction.

        Expression of Cap-H2EY09979 under the control of Scer\GAL4hs.PB does not result in DNA breaks detectable with TUNEL in the salivary glands.

        (Hartl et al., 2008)

        Expression of Cap-H2EY09979 under the control of Scer\GAL4hs.PB results in a drastic separation of salivary gland chromosomal components.

        (Hartl et al., 2008)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Suppressor of
        Statement
        Reference

        Scer\GAL4sd-SG29.1/Cap-H2EY09979 is a suppressor of visible | dominant phenotype of Ubx1:Cbx-1

        (Hartl et al., 2008)
        Phenotype Manifest In
        Suppressed by
        Statement
        Reference

        Cap-H2EY09979, Scer\GAL4hs.PB has polytene chromosome & larval salivary gland phenotype, suppressible by Cap-D3EY00456/Df(2L)Exel7023

        (Hartl et al., 2008)
        Suppressor of
        Statement
        Reference

        Scer\GAL4sd-SG29.1/Cap-H2EY09979 is a suppressor of wing phenotype of Ubx1:Cbx-1

        (Hartl et al., 2008)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Expression of Cap-H2EY09979 under the control of Scer\GAL4sd-SG29.1 partially suppresses the Ubx1:Cbx-1/+ wing phenotype.

        (Hartl et al., 2008)

        The polytene chromosome disassembly that is seen in larval salivary glands expressing Cap-H2EY09979 under the control of Scer\GAL4hs.PB is suppressed by Cap-D3EY00456/Df(2L)Exel7023.

        (Hartl et al., 2008)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        Cap-H2EY09979
        (Wallace et al., 2015, Herzog et al., 2013)
        Name Synonyms
        Secondary FlyBase IDs
          References (5)