FlyBase Allele Report: Dmel\Fcp1[c.UAS]

General Information

Symbol

Dmel\Fcp1^c.UAS

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Tombacz

FlyBase ID

FBal0220825

Feature type

allele

Associated gene

Dmel\Fcp1

Associated Insertion(s)

Carried in Construct

P{UAS-Fcp1.c}

Also Known As

UAST-fcp1

Key Links

Transgenic product class

cDNA

(Tombácz et al., 2009)

wild_type

(Tombácz et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Tombácz et al., 2009)

wild_type

(Tombácz et al., 2009)

Mutagen

in vitro construct

(Schauer et al., 2009, Tombácz et al., 2009)

Progenitor genotype

Carried in construct

P{UAS-Fcp1.c}

Cytology

Description

UASt regulatory sequences drive expression of a Fcp1 cDNA.

(Tombácz et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Fcp1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell death, with Scer\GAL4^Act5C.PU

(Schauer et al., 2009)

lethal, with Scer\GAL4^Act5C.PI

(Ciurciu et al., 2009)

lethal, with Scer\GAL4^Act5C.PU

(Schauer et al., 2009)

lethal, with Scer\GAL4^da.G32

(Schauer et al., 2009)

lethal, with Scer\GAL4^Tub.PU

(Schauer et al., 2009)

lethal - all die during embryonic stage, with Scer\GAL4^Act5C.PU

(Tombácz et al., 2009)

some die during embryonic stage, with Scer\GAL4^Act5C.PU

(Tombácz et al., 2009)

visible, with Scer\GAL4^en-e16E

(Schauer et al., 2009)

wild-type, with Fcp1^RNAi.UAS.WIZ, Scer\GAL4^Act5C.PU

(Tombácz et al., 2009)

Phenotype Manifest In

imaginal disc, with Scer\GAL4^Act5C.PU

(Schauer et al., 2009)

polytene chromosome puff, with Scer\GAL4^Act5C.PI

(Ciurciu et al., 2009)

wing, with Scer\GAL4^en-e16E

(Schauer et al., 2009)

Detailed Description

Statement

Reference

Scer\GAL4^Act5C.PI-mediated expression of P{UAS-Fcp1.c}89B results in formation of a detectable puff in the 89B region.

(Ciurciu et al., 2009)

Expression of Fcp1^Scer\UAS.cTa under the control of Scer\GAL4^Act5C results in extensive cell death in the imaginal discs (assessed by acridine orange staining).

(Schauer et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Fcp1^c.UAS, Scer\GAL4^en-e16E has visible phenotype, non-enhanceable by mei-41^RT1

(Schauer et al., 2009)

NOT suppressed by

Statement

Reference

Fcp1^c.UAS, Scer\GAL4^en-e16E has visible phenotype, non-suppressible by mei-41^RT1

(Schauer et al., 2009)

Fcp1^c.UAS, Scer\GAL4^da.G32 has lethal phenotype, non-suppressible by mei-41^RT1

(Schauer et al., 2009)

Other

Statement

Reference

Fcp1^c.UAS, Scer\GAL4^vg.PU, p53^H159N.UAS.Ex has visible phenotype

(Schauer et al., 2009)

Fcp1^c.UAS, Scer\GAL4^en-e16E, p53^H159N.UAS.Ex has lethal phenotype

(Schauer et al., 2009)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

Fcp1^c.UAS, Scer\GAL4^en-e16E has wing phenotype, non-enhanceable by mei-41^RT1

(Schauer et al., 2009)

NOT suppressed by

Statement

Reference

Fcp1^c.UAS, Scer\GAL4^en-e16E has wing phenotype, non-suppressible by mei-41^RT1

(Schauer et al., 2009)

Other

Statement

Reference

Fcp1^c.UAS, Scer\GAL4^vg.PU, p53^H159N.UAS.Ex has wing phenotype

(Schauer et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of p53^{H159N.Scer\UAS.Ex} and Fcp1^Scer\UAS.cTa under the control of Scer\GAL4^vg.PU results in a nicked wings phenotype (this phenotype is not seen when either transgene is expressed alone).

(Schauer et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Fcp1^c.UAS is rescued by Scer\GAL4^Act5C.PI/Fcp1^RNAi.UAS.WIZ

(Ciurciu et al., 2009)

Rescues

Fcp1^c.UAS/Scer\GAL4^Act5C.PI rescues Fcp1^RNAi.UAS.WIZ

(Ciurciu et al., 2009)

Comments

Scer\GAL4^Act5C.PI-mediated co-expression of both Fcp1^c.Scer\UAS and Fcp1^{dsRNA.Scer\UAS.WIZ} has no adverse effect and development is normal.

(Ciurciu et al., 2009)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Fcp1^Scer\UAS.cTa

Fcp1^c.Scer\UAS

Fcp1^c.UAS

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Tombacz

Secondary FlyBase IDs

References (3)

Report Sections

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