FlyBase Allele Report: Dmel\Hex-A[KK100831]

General Information

Symbol

Dmel\Hex-A^KK100831

Species

D. melanogaster

Name

FlyBase ID

FBal0230942

Feature type

allele

Associated gene

Dmel\Hex-A

Associated Insertion(s)

Carried in Construct

P{KK100831}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK100831}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK100831

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | third instar larval stage, with Scer\GAL4^en.PU

(Slaninova et al., 2016)

Phenotype Manifest In

wing disc posterior compartment | third instar larval stage, with Scer\GAL4^en.PU

(Slaninova et al., 2016)

Detailed Description

Statement

Reference

Expression of Hex-A^KK100831 under the control of Scer\GAL4^en.PU results in a small but significant decrease in size of the third instar wing disc posterior compartment, as compared to controls.

(Slaninova et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Hex-A^KK100831, Scer\GAL4^repo is a suppressor | partially of abnormal wound healing | larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Li et al., 2020)

Hex-A^KK100831, Scer\GAL4^repo is a suppressor | partially of abnormal wound healing | larval stage phenotype of Myc^UAS.cZa, Scer\GAL4^repo

(Li et al., 2020)

Hex-A^KK100831, Scer\GAL4^ptc.PU is a suppressor | partially of hyperplasia | third instar larval stage phenotype of N^UAS.icd, Scer\GAL4^ptc.PU

(Slaninova et al., 2016)

Other

Statement

Reference

Hex-A^KK100831, Ldh^KK102330, Scer\GAL4^en.PU has abnormal size | third instar larval stage phenotype

(Slaninova et al., 2016)

Phenotype Manifest In

Enhancer of

Statement

Reference

Hex-A^KK100831, Scer\GAL4^drm.7.1 is an enhancer of terminal tracheal cell | larval stage phenotype of Scer\GAL4^drm.7.1, trc^GL01127

(Hudson et al., 2023)

Suppressor of

Statement

Reference

Hex-A^KK100831, Scer\GAL4^repo is a suppressor | partially of larval multidendritic class IV neuron phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Li et al., 2020)

Hex-A^KK100831, Scer\GAL4^repo is a suppressor | partially of larval multidendritic class IV neuron phenotype of Myc^UAS.cZa, Scer\GAL4^repo

(Li et al., 2020)

Hex-A^KK100831, Scer\GAL4^ptc.PU is a suppressor | partially of wing disc | third instar larval stage phenotype of N^UAS.icd, Scer\GAL4^ptc.PU

(Slaninova et al., 2016)

Other

Statement

Reference

Hex-A^KK100831, Ldh^KK102330, Scer\GAL4^en.PU has wing disc posterior compartment | third instar larval stage phenotype

(Slaninova et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of Hex-A^KK100831 partially rescues the wing disc hyperplasia seen in larvae expressing N^Scer\UAS.icd under the control of Scer\GAL4^ptc.PU.

Co-expression of ImpL3^KK102330 and Hex-A^KK100831 under the control of Scer\GAL4^en.PU results in a significant decrease in size of the third instar wing disc posterior compartment, as compared to controls.

(Slaninova et al., 2016)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v104680

P{KK100831}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Hex-A^KK100831

Hex-A^RNAi

(Bonnay et al., 2020)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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