FlyBase Allele Report: Dmel\PTPMT1[KK108325]

General Information

Symbol

Dmel\PTPMT1^KK108325

Species

D. melanogaster

Name

FlyBase ID

FBal0235503

Feature type

allele

Associated gene

Dmel\PTPMT1

Associated Insertion(s)

Carried in Construct

P{KK108325}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK108325}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK108325

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates inclusion body myopathy with Paget disease of bone and frontotemporal dementia

modeled by TER94^R188Q.UAS

(Chang et al., 2011)

modeled by TER94^A229E.UAS

(Chang et al., 2011)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of Plip^KK108325 under the control of Scer\GAL4^ninaE.PT has no phenotypic effect on outer photoreceptor cells.

(Chang et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

PTPMT1^KK108325, Scer\GAL4^ninaE.PT is a non-enhancer of abnormal neuroanatomy phenotype of Scer\GAL4^ninaE.PT, TER94^K2A.UAS

(Chang et al., 2011)

Suppressor of

Statement

Reference

PTPMT1^KK108325, Scer\GAL4^ninaE.PT is a suppressor of abnormal neuroanatomy phenotype of Scer\GAL4^ninaE.PT, TER94^R188Q.UAS

(Chang et al., 2011)

PTPMT1^KK108325, Scer\GAL4^ninaE.PT is a suppressor of abnormal neuroanatomy phenotype of Scer\GAL4^ninaE.PT, TER94^A229E.UAS

(Chang et al., 2011)

NOT Suppressor of

Statement

Reference

PTPMT1^KK108325, Scer\GAL4^ninaE.PT is a non-suppressor of abnormal neuroanatomy phenotype of Scer\GAL4^ninaE.PT, TER94^K2A.UAS

(Chang et al., 2011)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

PTPMT1^KK108325, Scer\GAL4^ninaE.PT is a non-enhancer of outer photoreceptor cell phenotype of Scer\GAL4^ninaE.PT, TER94^K2A.UAS

(Chang et al., 2011)

Suppressor of

Statement

Reference

PTPMT1^KK108325, Scer\GAL4^ninaE.PT is a suppressor of outer photoreceptor cell phenotype of Scer\GAL4^ninaE.PT, TER94^R188Q.UAS

(Chang et al., 2011)

PTPMT1^KK108325, Scer\GAL4^ninaE.PT is a suppressor of outer photoreceptor cell phenotype of Scer\GAL4^ninaE.PT, TER94^A229E.UAS

(Chang et al., 2011)

NOT Suppressor of

Statement

Reference

PTPMT1^KK108325, Scer\GAL4^ninaE.PT is a non-suppressor of outer photoreceptor cell phenotype of Scer\GAL4^ninaE.PT, TER94^K2A.UAS

(Chang et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of Plip^KK108325 under the control of Scer\GAL4^ninaE.PT significantly suppresses the TER94^{R188Q.Scer\UAS} photoreceptor cell phenotype.

Co-expression of Plip^KK108325 under the control of Scer\GAL4^ninaE.PT significantly suppresses the TER94^{A229E.Scer\UAS} photoreceptor cell phenotype.

Co-expression of Plip^KK108325 under the control of Scer\GAL4^ninaE.PT has no significant effect on TER94^K2A.Scer\UAS-induced photoreceptor cell degradation.

(Chang et al., 2011)

Xenogenetic Interactions

Statement

Reference

Co-expression of Plip^KK108325 under the control of Scer\GAL4^ninaE.PT has no significant effect on Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1}-induced photoreceptor cell degradation.

(Chang et al., 2011)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v104774

P{KK108325}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

PTPMT1^KK108325

Plip^KK108325

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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