FlyBase Allele Report: Dmel\Vps60[KK109120]

General Information

Symbol

Dmel\Vps60^KK109120

Species

D. melanogaster

Name

FlyBase ID

FBal0236067

Feature type

allele

Associated gene

Dmel\Vps60

Associated Insertion(s)

Carried in Construct

P{KK109120}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK109120}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK109120

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell number, with Scer\GAL4^NP1624

(Berns et al., 2014)

Phenotype Manifest In

epithelium, with Scer\GAL4^NP1624

(Berns et al., 2014)

female germline cyst, with Scer\GAL4^NP1624

(Berns et al., 2014)

stalk follicle cell, with Scer\GAL4^NP1624

(Berns et al., 2014)

Detailed Description

Statement

Reference

Scer\GAL4^tj-NP1624-mediated expression results in elongated stalks owing to an increase in the number of cells connecting two egg chambers. The normal linear alignment of cysts within the germarium is also disturbed. Furthermore, a 4-fold increase in dividing epithelial cells is observed within and outside of the stem cell region of germaria.

(Berns et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^NP1624, Vps60^KK109120 has increased cell number phenotype, suppressible by N^KK102890, Scer\GAL4^NP1624

(Berns et al., 2014)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^NP1624, Vps60^KK109120 has epithelium phenotype, suppressible by N^KK102890, Scer\GAL4^NP1624

(Berns et al., 2014)

Scer\GAL4^NP1624, Vps60^KK109120 has stalk follicle cell phenotype, suppressible by N^KK102890, Scer\GAL4^NP1624

(Berns et al., 2014)

Scer\GAL4^NP1624, Vps60^KK109120 has female germline cyst phenotype, suppressible by N^KK102890, Scer\GAL4^NP1624

(Berns et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of N^KK102890 prevents the formation of elongated stalks, the disorganization of germaria, and the increased cell numbers seen in Vps60^KK109120 Scer\GAL4^tj-NP1624 mutants.

(Berns et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v101422

P{KK109120}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CG6259^KK109120

Vps60^KK109120

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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