FB2024_03 , released June 25, 2024
Allele: Dmel\painUAS.cTa
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General Information
Symbol
Dmel\painUAS.cTa
Species
D. melanogaster
Name
FlyBase ID
FBal0239189
Feature type
allele
Associated gene
Dmel\pain
Associated Insertion(s)
Carried in Construct
P{UAS-pain.T}
Also Known As
UAS-pain
Key Links
Transgenic product class
missense_variant
(Al-Anzi et al., 2006)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Al-Anzi et al., 2006)
Mutagen
in vitro construct
(Al-Anzi et al., 2006)
Progenitor genotype
Carried in construct
P{UAS-pain.T}
Cytology
Description

Amino acid replacement: S358R.

(Al-Anzi et al., 2006)

UASt regulatory sequences drive expression of wild-type pain coding region that contains a single nucleotide change difference to the published sequence, resulting in a single residue change S358R. This is not believed to affect the function.

(Al-Anzi et al., 2006)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
pain
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The courting ability of males expressing painScer\UAS.cTa under the control of Scer\GAL4pain-GAL4 appears similar to that of wild-type males.

      (Wang et al., 2011)

      Expression of painScer\UAS.cTa under the control of Scer\GAL4pain-GAL4 does not affect the time to copulation for female flies.

      (Sakai et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      painUAS.cTa/Scer\GAL4GH146 rescues painEP2451

      (Wang et al., 2011)

      painUAS.cTa/Scer\GAL4pain-GAL4 rescues painGAL4

      (Sakai et al., 2009)

      painUAS.cTa/Scer\GAL4pain-GAL4 rescues painEP2251

      (Sakai et al., 2009)

      painUAS.cTa/Scer\GAL4pain-GAL4 rescues painEP2451

      (Sakai et al., 2009)

      painUAS.cTa rescues painEP2451

      (Sun et al., 2009)

      painUAS.cTa/Scer\GAL4pain-GAL4 rescues painEP2621

      (Al-Anzi et al., 2006)
      Partially rescues

      painUAS.cTa/Scer\GAL4pain-GAL4 partially rescues painGAL4

      (Wang et al., 2011)

      painUAS.cTa/Scer\GAL4pain-GAL4 partially rescues painEP2451

      (Wang et al., 2011)
      Fails to rescue

      Scer\GAL4Ilp2.PU/painUAS.cTa fails to rescue painEP2621

      (Sakai et al., 2014)

      painUAS.cTa/Scer\GAL4Gr66a.PD fails to rescue painEP2451

      (Wang et al., 2011)
      Comments

      Expression of painScer\UAS.cTa in insulin producing cells under the control of Scer\GAL4Ilp2.PU is unable to rescue the increased sexual receptivity seen in painEP2621 mutant females.

      (Sakai et al., 2014)

      Expression of painScer\UAS.cTa in painEP2451 under the control of Scer\GAL4pain-GAL4 partially restores the avoidance to high levels of 4-methyl-cyclohexanol, but does not restore the low concentration avoidance.

      Expression of painScer\UAS.cTa in painGAL4 under the control of Scer\GAL4pain-GAL4 partially restores the avoidance to high levels of 4-methyl-cyclohexanol, but does not restore the low concentration avoidance.

      The intensity and duration of the male-male courtship behavior in painEP2451 flies is significantly reduced following preferential expression of painScer\UAS.cTa in Scer\GAL4GH146-expressing projection neurons.

      Overexpression of painScer\UAS.cTa in Scer\GAL4Gr66a.PD-expressing neurons does not prevent male-male courtship behavior in painEP2451 flies.

      (Wang et al., 2011)

      Expression of painScer\UAS.cTa under the control of Scer\GAL4pain-GAL4 in a homozygous mutant painEP2251, painEP2251, or painGAL4 background significantly lengthens the time to copulation in female flies to a level similar to control flies.

      (Sakai et al., 2009)

      Expression of painScer\UAS.cTa under the control of Scer\GAL4iav.PU rescues the geotaxis behaviour defects of painEP2451 mutants.

      (Sun et al., 2009)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      painScer\UAS.cAa
      painScer\UAS.cTa
      painUAS.cTa
      Name Synonyms
      Secondary FlyBase IDs
        References (5)