FlyBase Allele Report: Dmel\Cbl[S.UAS]

General Information

Symbol

Dmel\Cbl^S.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0240614

Feature type

allele

Associated gene

Dmel\Cbl

Associated Insertion(s)

Carried in Construct

P{UAS-Cbl.S}

Also Known As

UAS-Cbl-S

Key Links

Transgenic product class

cDNA

(Pai et al., 2006)

wild_type

(Pai et al., 2006)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Pai et al., 2006)

wild_type

(Pai et al., 2006)

Mutagen

in vitro construct

(Pai et al., 2006)

Progenitor genotype

Carried in construct

P{UAS-Cbl.S}

Cytology

Description

Expression of Cbl short isoform cDNA is under the control of UASt sequences.

(Pai et al., 2006)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Cbl

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

partially lethal - majority die, with Scer\GAL4^e22c

(Pai et al., 2006)

some die during P-stage, with Scer\GAL4^e22c

(Pai et al., 2006)

Phenotype Manifest In

adult abdominal segment, with Scer\GAL4^e22c

(Pai et al., 2006)

tergite, with Scer\GAL4^e22c

(Pai et al., 2006)

Detailed Description

Statement

Reference

Somatic clones expressing Cbl^S.UAS under the control of Scer\GAL4^Tub.PU show no obvious differences in the number of intestinal stem cells or the overall number of cells per clone compared to controls.

(Gervais et al., 2019)

Unlike Cbl^L.Scer\UAS, driving Cbl^S.Scer\UAS with Scer\GAL4^55B, Scer\GAL4^GR1 or Scer\GAL4^EQ1 does not lead to egg shell ventralisation and driving with does not produce rough eyes. However, driving with Scer\GAL4^GMR.PF causes mild wing defects and most Cbl^L.Scer\UAS; Scer\GAL4^e22c animals die during pupal stages. Some escapers have abdominal hemisegment fusions.

(Pai et al., 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Cbl^S.UAS, Rbf^120a, Scer\GAL4^{FRT.Rnor\Cd2.Act5C} has increased cell death phenotype, suppressible | partially by mir-998^UAS.cTa, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}

(Truscott et al., 2014)

Enhancer of

Statement

Reference

Scer\GAL4^{FRT.Rnor\Cd2.Act5C}/Cbl^S.UAS is an enhancer of increased cell death phenotype of Rbf^120a

(Truscott et al., 2014)

Suppressor of

Statement

Reference

Cbl^S.UAS, Scer\GAL4^Tub.PU is a suppressor | partially of increased cell number | somatic clone | adult stage phenotype of Scer\GAL4^Tub.PU, kis^HMS01254

(Gervais et al., 2019)

Phenotype Manifest In

Suppressed by

Statement

Reference

Cbl^S.UAS, Rbf^120a, Scer\GAL4^{FRT.Rnor\Cd2.Act5C} has eye disc phenotype, suppressible | partially by mir-998^UAS.cTa, Scer\GAL4^{FRT.Rnor\Cd2.Act5C}

(Truscott et al., 2014)

Enhancer of

Statement

Reference

Scer\GAL4^{FRT.Rnor\Cd2.Act5C}/Cbl^S.UAS is an enhancer of eye disc phenotype of Rbf^120a

(Truscott et al., 2014)

Suppressor of

Statement

Reference

Cbl^S.UAS, Scer\GAL4^Tub.PU is a suppressor | partially of adult midgut epithelium | somatic clone phenotype of Scer\GAL4^Tub.PU, kis^HMS01254

(Gervais et al., 2019)

Cbl^S.UAS, Scer\GAL4^Tub.PU is a suppressor | partially of intestinal stem cell | somatic clone | adult stage phenotype of Scer\GAL4^Tub.PU, kis^HMS01254

(Gervais et al., 2019)

Cbl^S.UAS is a suppressor | partially of dorsal appendage phenotype of Scer\GAL4^EQ1, btl::Egfr^λ.UAS

(Pai et al., 2006)

Additional Comments

Genetic Interactions

Statement

Reference

The generation of Cbl^S.Scer\UAS mutant eye disc clones enhances the amount of cell death seen in Rbf^120a mutant eye discs. Co-expression of mir-998^Scer\UAS.cTa blocks this suppression.

(Truscott et al., 2014)

The formation of extra dorsal appendage material in eggs laid by btl::Egfr^{Scer\UAS.T:λ\cI-DD}; Scer\GAL4^EQ1 mothers is only weakly suppressed by Cbl^S.Scer\UAS. The wing phenotypes of these animals are not suppressed by Cbl^S.Scer\UAS.

(Pai et al., 2006)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Cbl^S.Scer\UAS

Cbl^S.UAS

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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