FlyBase Allele Report: Dmel\Mkp3[P3]

General Information

Symbol

Dmel\Mkp3^P3

Species

D. melanogaster

Name

FlyBase ID

FBal0240671

Feature type

allele

Associated gene

Dmel\Mkp3

Associated Insertion(s)

P{EP}Mkp3^P3

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - molecular evidence

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

hypomorphic allele - molecular evidence

(Kim et al., 2004)

Mutagen

Delta2-3 transposase

(Kim et al., 2004)

Progenitor genotype

P{EP}MESR6^EP3142

(Kim et al., 2004)

Associated Insertion(s)

P{EP}Mkp3^P3

Cytology

Description

Mobilization of the P{EP}MESR6^EP3142 element, resulting in a P{EP} insertion within Mkp3; the insertion is located in intron 1, 489bp downstream of the translation start site.

(Kim et al., 2004)

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:19,085,234..19,085,234 [-]

(Kim et al., 2004)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell number | adult stage

(Kim et al., 2004)

increased cell number | adult stage (with Mkp3^P2)

(Kim et al., 2004)

viable

(Kim et al., 2004)

visible | adult stage

(Kim et al., 2004)

visible | adult stage (with Mkp3^P2)

(Kim et al., 2004)

Phenotype Manifest In

eye photoreceptor cell | adult stage | increased number (with Mkp3^P2)

(Kim et al., 2004)

photoreceptor cell R7 | adult stage | increased number

(Kim et al., 2004)

wing vein | ectopic

(Kim et al., 2004)

wing vein | ectopic (with Mkp3^P2)

(Kim et al., 2004)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Mkp3^P3 is an enhancer of increased cell number | adult stage phenotype of Raf^UAS.F179, Scer\GAL4^sev.PU

(Kim et al., 2004)

Mkp3^P3 is an enhancer of visible | adult stage phenotype of Raf^UAS.F179, Scer\GAL4^sev.PU

(Kim et al., 2004)

Mkp3^P3 is an enhancer of increased cell number | adult stage phenotype of Ras85D^V12.cUa.UAS, Scer\GAL4^sev.PU

(Kim et al., 2004)

Mkp3^P3 is an enhancer of visible | adult stage phenotype of Ras85D^V12.cUa.UAS, Scer\GAL4^sev.PU

(Kim et al., 2004)

Suppressor of

Statement

Reference

Mkp3^P3/Mkp3^P3 is a suppressor of visible | adult stage phenotype of Raf¹²

(Kim et al., 2004)

Mkp3^P3/Mkp3^P3 is a suppressor of decreased cell number | adult stage phenotype of Raf¹²

(Kim et al., 2004)

Mkp3^P3/Mkp3^P3 is a suppressor of increased mortality during development | temperature conditional phenotype of Raf¹²

(Kim et al., 2004)

Phenotype Manifest In

Enhancer of

Statement

Reference

Mkp3^P3 is an enhancer of eye photoreceptor cell | adult stage | increased number phenotype of Raf^UAS.F179, Scer\GAL4^sev.PU

(Kim et al., 2004)

Mkp3^P3 is an enhancer of ommatidium | adult stage phenotype of Raf^UAS.F179, Scer\GAL4^sev.PU

(Kim et al., 2004)

Mkp3^P3 is an enhancer of eye phenotype of Raf^UAS.F179, Scer\GAL4^sev.PU

(Kim et al., 2004)

Mkp3^P3 is an enhancer of eye photoreceptor cell | adult stage | increased number phenotype of Ras85D^V12.cUa.UAS, Scer\GAL4^sev.PU

(Kim et al., 2004)

Mkp3^P3 is an enhancer of ommatidium | adult stage phenotype of Ras85D^V12.cUa.UAS, Scer\GAL4^sev.PU

(Kim et al., 2004)

Mkp3^P3 is an enhancer of eye phenotype of Ras85D^V12.cUa.UAS, Scer\GAL4^sev.PU

(Kim et al., 2004)

Suppressor of

Statement

Reference

Mkp3^P3/Mkp3^P3 is a suppressor of eye phenotype of Raf¹²

(Kim et al., 2004)

Mkp3^P3/Mkp3^P3 is a suppressor of eye photoreceptor cell | adult stage | decreased number phenotype of Raf¹²

(Kim et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

DMKP-3^P3

(Kim et al., 2004)

Mkp3^P3

(Ha et al., 2009)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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