FlyBase Allele Report: Dmel\Sox14[Δ13]

General Information

Symbol

Dmel\Sox14^Δ13

Species

D. melanogaster

Name

FlyBase ID

FBal0242675

Feature type

allele

Associated gene

Dmel\Sox14

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Kirilly et al., 2009)

Progenitor genotype

P{Mae-UAS.6.11}LA00606

(Kirilly et al., 2009)

Cytology

Description

Imprecise excision of P{Mae-UAS.6.11}LA00606 removes the entire first exon of Sox14 with a deletion of 1964bps.

(Kirilly et al., 2009)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

2R:23,979,090..23,981,053 [+]

Comment:

A deletion resulting from the imprecise excision of P{Mae-UAS.6.11}LA00606 that removes 1964 bp of Sox14 including the first exon. Position of deletion on reference sequence inferred by FlyBase curator.

(Kirilly et al., 2009)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(Kirilly et al., 2009)

abnormal neuroanatomy (with Df(2R)BSC136)

(Kirilly et al., 2009)

abnormal neuroanatomy (with Sox14^Δ15)

(Kirilly et al., 2009)

abnormal neuroanatomy | pupal stage | somatic clone

(Wong et al., 2013)

lethal - all die before end of pupal stage

(Kirilly et al., 2009)

some die during pupal stage

(Kirilly et al., 2009)

Phenotype Manifest In

Detailed Description

Statement

Reference

Sox14^Δ13 mutant ddaC neuron clones exhibit dendrite pruning defects at 16 hours after puparium formation. No difference is seen at the white prepupal stage.

(Wong et al., 2013)

The majority of the primary and secondary dendrites remain attached to the ddaC soma at 18h APF and 24h APF compared with white prepupae in Sox14^Δ13 homozygotes, Sox14^Δ13/Sox14^Δ15 and Sox14^Δ13/Df(2R)BSC136 transheterozygotes, indicating no dendritic pruning has occurred.

(Kirilly et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Sox14^Δ13 has abnormal neuroanatomy | pupal stage | somatic clone phenotype, non-enhanceable by Cul1^EX

(Wong et al., 2013)

Suppressed by

Statement

Reference

Sox14^Δ13 has abnormal neuroanatomy phenotype, suppressible | partially by Scer\GAL4^109(2)80/Mical^UAS.fl

(Kirilly et al., 2009)

NOT suppressed by

Statement

Reference

Sox14^Δ13 has abnormal neuroanatomy phenotype, non-suppressible by Scer\GAL4^109(2)80/Mical^N-ter.UAS

(Kirilly et al., 2009)

NOT Enhancer of

Statement

Reference

Sox14^Δ13 is a non-enhancer of abnormal neuroanatomy | pupal stage | somatic clone phenotype of Cul1^EX

(Wong et al., 2013)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

Sox14^Δ13 has larval dorsal multidendritic neuron ddaC | pupal stage | somatic clone phenotype, non-enhanceable by Cul1^EX

(Wong et al., 2013)

Suppressed by

Statement

Reference

Sox14^Δ13 has dendrite phenotype, suppressible | partially by Scer\GAL4^109(2)80/Mical^UAS.fl

(Kirilly et al., 2009)

Sox14^Δ13 has larval dorsal multidendritic neuron ddaC phenotype, suppressible | partially by Scer\GAL4^109(2)80/Mical^UAS.fl

(Kirilly et al., 2009)

NOT suppressed by

Statement

Reference

Sox14^Δ13 has dendrite phenotype, non-suppressible by Scer\GAL4^109(2)80/Mical^N-ter.UAS

(Kirilly et al., 2009)

Sox14^Δ13 has larval dorsal multidendritic neuron ddaC phenotype, non-suppressible by Scer\GAL4^109(2)80/Mical^N-ter.UAS

(Kirilly et al., 2009)

NOT Enhancer of

Statement

Reference

Sox14^Δ13 is a non-enhancer of larval dorsal multidendritic neuron ddaC | pupal stage | somatic clone phenotype of Cul1^EX

(Wong et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

Sox14^Δ13 lin19^EX double mutant ddaC neuron clones have similar dendrite pruning defects at 16 hours after puparium formation as are seen in either single mutant alone.

(Wong et al., 2013)

Expression of Mical^{N-ter.Scer\UAS} in ddaC neurons under the control of Scer\GAL4^109(2)80 in a Sox14^Δ13 homozygous background fails to affect the excess dendritic arborization found in Sox14^Δ13 mutants.

Expression of Mical^Scer\UAS.fl in ddaC neurons under the control of Scer\GAL4^109(2)80 in a Sox14^Δ13 homozygous background partially suppresses the excess dendritic arborization found in Sox14^Δ13 mutants.

(Kirilly et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Sox14^Δ15/Sox14^Δ13 is rescued by Scer\GAL4^109(2)80/Sox14^fl.UAS

(Kirilly et al., 2009)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Sox14^Δ13

(Kirilly et al., 2009)

sox14^Δ13

(Wong et al., 2013)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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