FlyBase Allele Report: Dmel\Gug[RNAi.1.UAS]

General Information

Symbol

Dmel\Gug^RNAi.1.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0243873

Feature type

allele

Associated gene

Dmel\Gug

Associated Insertion(s)

Carried in Construct

P{UAS-Gug.RNAi.1}

Key Links

Transgenic product class

RNAi_reagent

(Wang et al., 2008)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Wang et al., 2008)

Mutagen

in vitro construct

(Wang et al., 2008)

Progenitor genotype

Carried in construct

P{UAS-Gug.RNAi.1}

Cytology

Description

UAS regulatory sequences drive expression of Gug double-stranded RNA.

(Wang et al., 2008)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Gug

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal behavior | male limited, with Scer\GAL4^elav-C155

(Davis et al., 2014)

Phenotype Manifest In

wing vein | ectopic, with Scer\GAL4^dpp.blk1

(Wang et al., 2008)

Detailed Description

Statement

Reference

Male flies expressing Gug^{dsRNA.1.Scer\UAS} under the control of Scer\GAL4^50y show increased fighting frequency compared with control animals.

(Davis et al., 2014)

Expression of Gug^{dsRNA.1.Scer\UAS} in the L3 and L4 inter-vein region under the control of Scer\GAL4^dpp.blk1 results in ectopic wing vein formation.

No animals expressing Gug^{dsRNA.1.Scer\UAS} under the control of Scer\GAL4^dpp.blk1 develop melanotic masses in their heads.

No Gug³⁵ mutant males expressing Gug^{dsRNA.1.Scer\UAS} under the control of Scer\GAL4^dpp.blk1 develop melanotic masses in their heads.

(Wang et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Other

Statement

Reference

Gug^RNAi.1.UAS, HDAC1⁰⁴⁵⁵⁶, Scer\GAL4^dpp.blk1 has adult head phenotype

(Wang et al., 2008)

Gug^RNAi.1.UAS, HDAC1⁰⁴⁵⁵⁶, Scer\GAL4^dpp.blk1 has melanotic mass phenotype

(Wang et al., 2008)

G9a^del34, Gug^RNAi.1.UAS, Scer\GAL4^dpp.blk1 has adult head phenotype

(Wang et al., 2008)

G9a^del34, Gug^RNAi.1.UAS, Scer\GAL4^dpp.blk1 has melanotic mass phenotype

(Wang et al., 2008)

G9a^RG5, Gug^RNAi.1.UAS, Scer\GAL4^dpp.blk1 has adult head phenotype

(Wang et al., 2008)

G9a^RG5, Gug^RNAi.1.UAS, Scer\GAL4^dpp.blk1 has melanotic mass phenotype

(Wang et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

6.1% of Rpd3⁰⁴⁵⁵⁶ mutant males expressing Gug^{dsRNA.1.Scer\UAS} under the control of Scer\GAL4^dpp.blk1 develop melanotic masses in their heads.

No Rpd3³¹³ mutant males expressing Gug^{dsRNA.1.Scer\UAS} under the control of Scer\GAL4^dpp.blk1 develop melanotic masses in their heads.

37.5% of G9a^RG5 mutant males expressing Gug^{dsRNA.1.Scer\UAS} under the control of Scer\GAL4^dpp.blk1 develop melanotic masses in their heads.

30.7% of G9a^del34 mutant males expressing Gug^{dsRNA.1.Scer\UAS} under the control of Scer\GAL4^dpp.blk1 develop melanotic masses in their heads.

(Wang et al., 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Gug^RNAi.1.UAS is rescued by Gug^UAS.cCa/Scer\GAL4^dpp.blk1

(Wang et al., 2008)

Comments

Expression of Gug^{dsRNA.1.Scer\UAS} in the L3 and L4 inter-vein region under the control of Scer\GAL4^dpp.blk1 results in ectopic wing vein formation, which is rescued by co-expression of Gug^Scer\UAS.cCa.

(Wang et al., 2008)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Gug^RNAi.1.UAS

Gug^{dsRNA.1.Scer\UAS}

Gug^dsRNA.1.UAS

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

Open Close