FB2024_03 , released June 25, 2024
Allele: Dmel\Pink1JF01672
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General Information
Symbol
Dmel\Pink1JF01672
Species
D. melanogaster
Name
FlyBase ID
FBal0245885
Feature type
allele
Associated gene
Dmel\Pink1
Associated Insertion(s)
Carried in Construct
P{TRiP.JF01672}
Also Known As
Pink1 RNAi
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Ni et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Ni et al., 2008)
Mutagen
in vitro construct
(Ni et al., 2008)
Progenitor genotype
Carried in construct
P{TRiP.JF01672}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat.

(Ni et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-JF01672
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  Parkinson's disease 6
      CEA
      (Zhou et al., 2019, Valadas et al., 2018)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expressing Pink1JF01672 under the control of Scer\GAL4Cg.PA leads to mitochondrial defects in the third instar larval fat body, including enlarged, fragmented and/or clustered mitochondria (as assessed by MitoGFP).

      Expressing Pink1JF01672 under the control of Scer\GAL4Mef2.PR leads to a significant decrease in adult climbing ability.

      (Zhou et al., 2019)

      The expression of Pink1JF01672 under the control of Scer\GAL4Act.PU in clones within mosaic midguts results in enterocytes during pupariation exhibiting a significant increase in the transverse cell area, a significant decrease in the relative amount of autophagosomes, as assessed by a Atg8a fluorescent reporter, and a significant increase in the relative mitochondrial content, as compared to non-clone enterocytes; however, no significant change in the relative mitochondrial content is observed at 4 hours after puparium formation, as compared to non-clone enterocytes.

      (Liu et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhanced by
      NOT suppressed by
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      The increased relative mitochondrial content and the decreased relative amount of autophagosomes observed during pupariation in enterocytes within midgut clones expressing Pink1JF01672 under the control of Scer\GAL4Act.PU are suppressed by the clonal co-expression of Hsap\PARK2Scer\UAS.cYa, even leading to a significant decrease in relative mitochondrial content and a significant increase in relative amount of autophagosomes, as compared to non-clone enterocytes.

      (Liu et al., 2016)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Pink1JF01672
      Name Synonyms
      Secondary FlyBase IDs
        References (8)