FlyBase Allele Report: Dmel\Diap2[UAS.cLa]

General Information

Symbol

Dmel\Diap2^UAS.cLa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Leulier

FlyBase ID

FBal0246795

Feature type

allele

Associated gene

Dmel\Diap2

Associated Insertion(s)

Carried in Construct

P{UAS-Diap2.L}

Also Known As

UAS-DIAP2^WT, UAS-diap2

Key Links

Transgenic product class

wild_type

(Leulier et al., 2006)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Leulier et al., 2006)

Mutagen

in vitro construct

(Ribeiro et al., 2007, Leulier et al., 2006)

Progenitor genotype

Carried in construct

P{UAS-Diap2.L}

Cytology

Description

UASt regulatory sequences drive expression of Diap2.

(Leulier et al., 2006)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Diap2

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Diap2^UAS.cLa, Scer\GAL4^hs.2sev is a non-enhancer of increased cell death phenotype of Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev

(Yang et al., 2013)

NOT Suppressor of

Statement

Reference

Scer\GAL4^ey-OK107/Diap2^UAS.cLa is a non-suppressor of abnormal neuroanatomy | somatic clone | adult stage | progressive phenotype of bsk^flp147E

(Rallis et al., 2013)

Diap2^UAS.cLa, Scer\GAL4^hs.2sev is a non-suppressor of increased cell death phenotype of Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

Diap2^UAS.cLa, Scer\GAL4^hs.2sev is a non-enhancer of eye phenotype of Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Suppressor of

Statement

Reference

Scer\GAL4^GMR.PF/Diap2^UAS.cLa is a suppressor of eye phenotype of Diap1^RNAi.UAS.cLa

(Ribeiro et al., 2007)

NOT Suppressor of

Statement

Reference

Scer\GAL4^ey-OK107/Diap2^UAS.cLa is a non-suppressor of alpha/beta Kenyon cell phenotype of bsk^flp147E

(Rallis et al., 2013)

Scer\GAL4^ey-OK107/Diap2^UAS.cLa is a non-suppressor of gamma Kenyon cell phenotype of bsk^flp147E

(Rallis et al., 2013)

Diap2^UAS.cLa, Scer\GAL4^hs.2sev is a non-suppressor of eye phenotype of Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of Iap2^Scer\UAS.cLa under the control of Scer\GAL4^ey-OK107 fails to suppress the axon degeneration seen in bsk^flp147E mutant mushroom body neuron clones.

(Rallis et al., 2013)

The small eye phenotype observed in animals expressing th^{dsRNA.Scer\UAS.cLb} under the control of Scer\GAL4^GMR.PF is suppressed by co-expression of Iap2^Scer\UAS.cRa.

(Ribeiro et al., 2007)

Xenogenetic Interactions

Statement

Reference

Inhibition of apoptosis, through co-expression of Iap2^Scer\UAS.cLa does not affect the Mmus\Gria1^Lc.Scer\UAS eye defect (when all are expressed under the control of Scer\GAL4^hs.2sev.

(Yang et al., 2013)

Complementation and Rescue Data

Rescues

Scer\GAL4^da.G32/Diap2^UAS.cLa rescues Diap2^7c

(Meinander et al., 2012)

Diap2^UAS.cLa rescues Diap2^7c

(Leulier et al., 2006)

Scer\GAL4^Act5C.PU/Diap2^UAS.cLa rescues Diap2^7c

(Leulier et al., 2006)

Scer\GAL4^da.G32/Diap2^UAS.cLa rescues Diap2^7c

(Leulier et al., 2006)

Comments

Expression of Iap2^Scer\UAS.cLa under the control of Scer\GAL4^da.G32 rescues the reduced survival after septic injury with Erwinia carotovora carotovora 15 which is seen in Iap2^7c flies.

(Meinander et al., 2012)

"Leaky" low-level expression of Iap2^Scer\UAS.cLa in a Iap2^7c mutant background is sufficient to completely rescue the immunodeficient phenotype observed in Iap2^7c mutant animals in response to infection by gram-negative bacteria.

Iap2^7c mutant animals expressing Iap2^Scer\UAS.cLa, under the control of Scer\GAL4^Act5C or Scer\GAL4^da.G32, are fully resistant to infection by gram-negative bacterium and survive microbial exposure at a similar rate to wild-type.

(Leulier et al., 2006)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

99692

w^*; P{UAS-Diap2.L}3

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

Diap2^Scer\UAS.cLa

Diap2^UAS.cLa

Diap2^WT

(Meinander et al., 2012)

Iap2^Scer\UAS.cLa

Iap2^Scer\UAS.cRa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Leulier

(Leulier et al., 2006)

Saccharomyces cerevisiae UAS construct a of Ribeiro

(Ribeiro et al., 2007)

Secondary FlyBase IDs

FBal0244197
FBal0243968

References (6)

Report Sections

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