FB2024_03 , released June 25, 2024
Allele: Dmel\lncRNA:roX1UAS.cKa
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General Information
Symbol
Dmel\lncRNA:roX1UAS.cKa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Kelley
FlyBase ID
FBal0248388
Feature type
allele
Associated gene
Dmel\lncRNA:roX1
Associated Insertion(s)
Carried in Construct
P{UAS-roX1.K}
Key Links
Transgenic product class
cDNA
(Kelley et al., 2008)
wild_type
(Kelley et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Kelley et al., 2008)
wild_type
(Kelley et al., 2008)
Mutagen
in vitro construct
(Kelley et al., 2008)
Progenitor genotype
Carried in construct
P{UAS-roX1.K}
Cytology
Description

UASt regulatory sequences drive expression of a 3.4kb lncRNA:roX1 cDNA.

(Kelley et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
lncRNA:roX1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The presence of roX1Scer\UAS.cKa (without a Scer\GAL4 driver) fails to rescue the viability found in roX1MB710 Df(1)52 double mutant males. When the polytene chromosomes of these dying males are examined, the X chromosome exhibits collapsed morphology and very low levels of bound MSL proteins. However, the autosomal region around the transgene insertion site (within 1-2Mbp) is heavily coated with MSL complex in all nuclei.

      Expression of roX1Scer\UAS.cKa under the control of Scer\GAL4Act5C.PU dramatically increases male viability.

      (Kelley et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      lncRNA:roX1Scer\UAS.cKa
      lncRNA:roX1UAS.cKa
      roX1Scer\UAS.cKa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Kelley
      Saccharyomyces cerevisiae UAS construct a of Kelley
      Secondary FlyBase IDs
        References (3)