FB2024_03 , released June 25, 2024
Allele: Dmel\Bap170C1.UAS
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General Information
Symbol
Dmel\Bap170C1.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0248502
Feature type
allele
Associated gene
Dmel\Bap170
Associated Insertion(s)
Carried in Construct
P{UAS-Bap170.C1}
Key Links
Transgenic product class
wild_type
(Rendina et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Rendina et al., 2010)
Mutagen
in vitro construct
(Rendina et al., 2010)
Progenitor genotype
Carried in construct
P{UAS-Bap170.C1}
Cytology
Description

UAS regulatory sequences drive expression of the Bap170 C1 isoform.

(Rendina et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Bap170
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Bap170hfl1 adults which have been rescued by expression of Bap170C1.Scer\UAS under the control of Scer\GAL4Dll-md23 have eyes that are slightly larger than normal and have a rough appearance. The ommatidia often have more than the normal number of photoreceptor cells (some have extra outer photoreceptors, some have an extra putative R7 cell) and often have more than the normal four cone cells.

      (Rendina et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Other
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of Bap170C1.Scer\UAS enhances the loss of wing vein L4 that is seen in flies expressing Ras85DN17.Scer\UAS under the control of Scer\GAL4bi.PU, such that there is a loss of the entire L4 vein distal to the posterior crossvein. The distal end of wing vein L3 is missing in these flies and a reduction in wing surface area and occasional notching of the wing margin is also seen.

      Expression of Bap170C1.Scer\UAS under the control of Scer\GAL4Bx-MS1096 enhances the loss of wing vein L4 that is seen in Egfrf24/EgfrT1 flies, such that there is a loss of the entire L4 vein. In addition the central region of wing vein L3 does not form.

      Ras85De1B flies which are also expressing Bap170C1.Scer\UAS under the control of Scer\GAL4hs.2sev have rough eyes and lack all R7 photoreceptor cells.

      Expression of Bap170C1.Scer\UAS under the control of Scer\GAL4elav.PU enhances the rough eye phenotype and loss of photoreceptor cells seen in pntΔ88/pnt1277 flies.

      (Rendina et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Bap170C1.UAS/Scer\GAL4Tub.PU rescues Bap170Δ135

      (Rendina et al., 2010)

      Bap170C1.UAS/Scer\GAL4Tub.PU rescues Bap170hfl1

      (Rendina et al., 2010)
      Partially rescues

      Bap170C1.UAS/Scer\GAL4Dll-md23 partially rescues Bap170hfl1

      (Rendina et al., 2010)
      Comments

      Expression of Bap170C1.Scer\UAS under the control of Scer\GAL4tub.PU rescues the lethality of Bap170hfl1 and Bap170Δ135 homozygotes.

      Expression of Bap170C1.Scer\UAS under the control of Scer\GAL4Dll-md23 rescues the prepupal lethality of Bap170hfl1 homozygotes.

      (Rendina et al., 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Bap170C1.Scer\UAS
      Bap170C1.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)