FB2024_03 , released June 25, 2024
Allele: Dmel\mir-313UAS.cluster
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General Information
Symbol
Dmel\mir-313UAS.cluster
Species
D. melanogaster
Name
FlyBase ID
FBal0248879
Feature type
allele
Associated gene
Dmel\mir-313
Associated Insertion(s)
Carried in Construct
P{UAS-mir-310.cluster.DsRed}
Key Links
Transgenic product class
wild_type
(Tsurudome et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Tsurudome et al., 2010)
Mutagen
in vitro construct
(Tsurudome et al., 2010)
Progenitor genotype
Carried in construct
P{UAS-mir-310.cluster.DsRed}
Cytology
Description

UAS regulatory sequences drive expression of an 800 bp fragment carrying mir-310, mir-311, mir-312 and mir-313 cloned into the 3'-UTR of a DsRed2.

(Tsurudome et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
mir-313
Tagged with
DsRed2
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies expressing P{UAS-mir-310.cluster.DsRed} (which consists of the mir-310Scer\UAS.cluster, mir-311Scer\UAS.cluster, mir-312Scer\UAS.cluster and mir-313Scer\UAS.cluster alleles) under the control of Scer\GAL4Act5C.PU and limited to 16 hours of development onwards using Scer\GAL80ts.αTub84B exhibit increased sensitivity to nicotine.

      (Sanchez-Díaz et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of P{UAS-mir-310.cluster.DsRed} (which consists of the mir-310Scer\UAS.cluster, mir-311Scer\UAS.cluster, mir-312Scer\UAS.cluster and mir-313Scer\UAS.cluster alleles) under the control of Scer\GAL4L4 enhances the cuticle phenotype seen in esgL4 mutant flies, with 100% of the resulting flies having phenotype compared to 8% in esgL4/+. Only 14% of the flies are viable compared with 100% in esgL4/+. The increased nicotine sensitivity is also enhanced.

      Expression of esgEU143 partially suppresses the semi-lethality seen when P{UAS-mir-310.cluster.DsRed} (which consists of the mir-310Scer\UAS.cluster, mir-311Scer\UAS.cluster, mir-312Scer\UAS.cluster and mir-313Scer\UAS.cluster alleles) is expressed under the control of Scer\GAL4L4.

      (Sanchez-Díaz et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments

      Expression of P{UAS-mir-310.cluster.DsRed} (overexpression of mir-310,mir-311, mir-312 and mir-313) under the control of Scer\GAL4GMR.PU rescues the premature termination phenotype seen in the optic lobes of Df(2R)KT40 mutant flies.

      (Yatsenko et al., 2014)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      mir-313Scer\UAS.cluster
      mir-313UAS.cluster
      Name Synonyms
      Secondary FlyBase IDs
        References (3)