FB2024_03 , released June 25, 2024
Allele: Hsap\MAPTUAS.B
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General Information
Symbol
Hsap\MAPTUAS.B
Species
H. sapiens
Name
FlyBase ID
FBal0256678
Feature type
allele
Associated gene
Hsap\MAPT
Associated Insertion(s)
Carried in Construct
P{UAS-MAPT.B}
Key Links
Transgenic product class
wild_type
(Singh and Mahoney, 2011.2.17)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Singh and Mahoney, 2011.2.17)
Mutagen
in vitro construct
(Singh and Mahoney, 2011.2.17)
Progenitor genotype
Carried in construct
P{UAS-MAPT.B}
Cytology
Description

UAS drives expression of the 2n4r isoform of Hsap\MAPT. (This construct has more 5' and 3' UTR sequence than P{UAS-MAPT.VTR}.)

(Singh and Mahoney, 2011.2.17)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hsap\MAPT
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  tauopathy
      CEA
      (Minjarez et al., 2016, Kosmidis et al., 2010)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      model of  tauopathy
      is exacerbated by Sfxn1-3d06383
      (Minjarez et al., 2016)
      is exacerbated by Rho1RNAi.UAS.cBa
      (Minjarez et al., 2016)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Hsap\MAPTScer\UAS.B under the control of Scer\GAL4GMR.PU results in a disruption of the eye ommatidial lattice in adults.

      (Minjarez et al., 2016)

      Pan-neuronal expression of Hsap\MAPTScer\UAS.B under the control of Scer\GAL4elav.PU results in severe mushroom body defects.

      Temperature shift experiments reveal that conditional expression of Hsap\MAPTScer\UAS.B under the control of Scer\GAL4elav.PU and Scer\GAL80ts.αTub84B during the first 4 h of embryogenesis at 19[o]C does not affect adult MB structure. In contrast, continued expression of Hsap\MAPTScer\UAS.B 8 h into embryogenesis results in MB abnormalities in adults. Continued expression of Hsap\MAPTScer\UAS.B up to 14 h after egg laying does not result in more severe deficits.

      (Kosmidis et al., 2010)

      Expression of Hsap\MAPTScer\UAS.B under the control of Scer\GAL4elav.PU results in severe and specific mushroom body defects.

      Associative olfactory learning is nearly abolished in adult animals expressing Hsap\MAPTScer\UAS.B under the control of Scer\GAL4elav.PU.

      (Papanikolopoulou et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      NOT Enhanced by
      Statement
      Reference

      Hsap\MAPTUAS.B, Scer\GAL4GMR.PU has eye | adult stage phenotype, non-enhanceable by Pgm1HMS01333, Scer\GAL4GMR.PU

      (Minjarez et al., 2016)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      The defective eye morphology (disrupted ommatidial lattice) observed in adult flies expressing Hsap\MAPTScer\UAS.B under the control of Scer\GAL4GMR.PU is significantly worsened by co-expression of Rho1dsRNA.Scer\UAS RNAi with necrotic spots appearing in the posterior eye. Combination with CG11739d06383 also enhances the aberrant eye phenotype as the eye size is much reduced, whereas co-expression of PgmHMS01333 RNAi has no apparent effect.

      (Minjarez et al., 2016)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Made by Juan Botas (Baylor College of Medicine).

      (Singh and Mahoney, 2011.2.17)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\MAPTScer\UAS.B
      Hsap\MAPTUAS.B
      Name Synonyms
      Secondary FlyBase IDs
        References (5)